Sepsis is a deadly inflammatory syndrome caused by an exaggerated immune response to
infection. Much has been focused on host response to pathogens mediated through the …

Cold-inducible RNA-binding protein (CIRP) was discovered 2 decades ago while studying
the mechanism of cold stress adaptation in mammals. Since then, the role of intracellular …

RNA-binding proteins (RBPs) are of fundamental importance for post-transcriptional gene
regulation and protein synthesis. They are required for pre-mRNA processing and for RNA …

Cold-inducible RNA-binding protein (CIRP) is an intracellular stress-response protein and a
type of damage-associated molecular pattern (DAMP) that responds to various stress …

The triggering receptor expressed on myeloid cells-1 (TREM-1) is a pattern recognition
receptor, which can be upregulated in inflammatory diseases as an amplifier of immune …

Several molecular patterns have been identified that recognize pattern recognition
receptors. Pathogen-associated molecular patterns (PAMPs) and damage-associated …

Objective: Severe acute pancreatitis (SAP) can lead to acute lung injury (ALI). This study
investigated the therapeutic effect of emodin and its molecular mechanisms in a rat model of …

Sepsis is characterized by life-threatening organ dysfunction caused by a dysregulated host
response to infection. Extracellular cold-inducible RNA-binding protein (eCIRP) is a damage …

Sepsis is an infectious inflammatory disease that often results in acute lung injury (ALI). Cold-
inducible RNA-binding protein (CIRP) is an intracellular RNA chaperon that binds to …

Associated with the development of hospital-acquired infections, major traumatic injury
results in an immediate and persistent state of systemic immunosuppression, yet the …