[HTML][HTML] Pathophysiology of environmental enteric dysfunction and its impact on oral vaccine efficacy
C Marie, A Ali, K Chandwe, WA Petri Jr, P Kelly - Mucosal immunology, 2018 - Elsevier
Environmental enteric dysfunction (EED) refers to a subclinical disorder of intestinal function
common in tropical countries and in settings of poverty and economic disadvantage. The …
common in tropical countries and in settings of poverty and economic disadvantage. The …
Adaptation of the small intestine to microbial enteropathogens in Zambian children with stunting
B Amadi, K Zyambo, K Chandwe, E Besa… - Nature …, 2021 - nature.com
Environmental enteropathy is a major contributor to growth faltering in millions of children in
Africa and South Asia. We carried out a longitudinal, observational and interventional study …
Africa and South Asia. We carried out a longitudinal, observational and interventional study …
Gene expression profiles compared in environmental and malnutrition enteropathy in Zambian children and adults
P Kelly, B Amadi, K Chandwe, E Besa, K Zyambo… - …, 2021 - thelancet.com
Background: Environmental enteropathy (EE) contributes to growth failure in millions of
children worldwide, but its relationship to clinical malnutrition has not been elucidated. We …
children worldwide, but its relationship to clinical malnutrition has not been elucidated. We …
[HTML][HTML] Growth faltering regardless of chronic diarrhea is associated with mucosal immune dysfunction and microbial dysbiosis in the gut lumen
NS Rhoades, SM Hendrickson, K Prongay, A Haertel… - Mucosal …, 2021 - Elsevier
Despite the impact of childhood diarrhea on morbidity and mortality, our understanding of its
sequelae has been significantly hampered by the lack of studies that examine samples …
sequelae has been significantly hampered by the lack of studies that examine samples …
Healthcare professionals' knowledge of pharmacogenetics and attitudes towards antimicrobial utilization in Zambia: implications for a precision medicine approach to …
W Mufwambi, J Stingl, C Masimirembwa… - Frontiers in …, 2021 - frontiersin.org
Introduction: Sub-Saharan Africa and other low-and middle-income countries (LMICs) have
the highest rates of antimicrobial resistance (AMR) driven by high rates of antimicrobial …
the highest rates of antimicrobial resistance (AMR) driven by high rates of antimicrobial …
Rotavirus breakthrough infections responsible for gastroenteritis in vaccinated infants who presented with acute diarrhoea at University Teaching Hospitals, Children's …
Background In Zambia, before rotavirus vaccine introduction, the virus accounted for about
10 million episodes of diarrhoea, 63 000 hospitalisations and 15 000 deaths in 2015 …
10 million episodes of diarrhoea, 63 000 hospitalisations and 15 000 deaths in 2015 …
[HTML][HTML] Plasma Endotoxin Levels Are Not Increased in Schistosoma Mansoni–Infected Women Without Signs or Symptoms of Hepatosplenic Disease
KM Klemperer, MJ Reust, MH Lee… - The American Journal …, 2020 - ncbi.nlm.nih.gov
Elevated circulating endotoxin levels in the plasma of patients with advanced hepatosplenic
schistosomiasis caused by Schistosoma mansoni have been reported, possibly caused by …
schistosomiasis caused by Schistosoma mansoni have been reported, possibly caused by …
The role of environmental enteric dysfunction in the pathogenesis of Schistosoma mansoni-associated morbidity in school-aged children
J Araújo Fiuza, S Colt… - PLOS Neglected …, 2022 - journals.plos.org
Background Studies have implicated schistosomiasis as a cause of intestinal barrier
disruption, a salient feature of environmental enteric dysfunction (EED), as eggs translocate …
disruption, a salient feature of environmental enteric dysfunction (EED), as eggs translocate …
Prognostic model for nephrotoxicity among HIV-positive Zambian adults receiving tenofovir disoproxil fumarate-based antiretroviral therapy
FW Chabala, ED Siew, W Mutale, L Mulenga… - Plos one, 2021 - journals.plos.org
Persons living with HIV (PLWH) receiving tenofovir disoproxil fumarate (TDF)-based
antiretroviral therapy (ART) risk suffering TDF-associated nephrotoxicity (TDFAN). TDFAN …
antiretroviral therapy (ART) risk suffering TDF-associated nephrotoxicity (TDFAN). TDFAN …
Rationale and design of a screening study to detect schistosomiasis‐associated pulmonary hypertension in Ethiopia and Zambia
E Sinkala, HY Ahmed, JP Sibomana… - Pulmonary …, 2022 - Wiley Online Library
Schistosomiasis is a major cause of pulmonary arterial hypertension (PAH) worldwide, but
the prevalence and risk factors for schistosomiasis‐associated PAH (SchPAH) development …
the prevalence and risk factors for schistosomiasis‐associated PAH (SchPAH) development …