To migrate, a cell first extends protrusions such as lamellipodia and filopodia, forms
adhesions, and finally retracts its tail. The actin cytoskeleton plays a major role in this …

Endocytosis includes a number of processes by which cells internalize segments of their
plasma membrane, enclosing a wide variety of material from outside the cell. Endocytosis …

Peroxisomes have long been established to play a central role in regulating various
metabolic activities in mammalian cells. These organelles act in concert with mitochondria to …

Clathrin-mediated endocytosis is independent of actin dynamics in many circumstances but
requires actin polymerization in others. We show that membrane tension determines the …

The plasma membrane and the underlying cortical actin cytoskeleton undergo continuous
dynamic interplay that is responsible for many essential aspects of cell physiology …

The GTPase dynamin, a key player in endocytic membrane fission, interacts with numerous
proteins that regulate actin dynamics and generate/sense membrane curvature. To …

Our understanding of endocytosis has evolved remarkably in little more than a decade. This
is the result not only of advances in our knowledge of its molecular and biological workings …

Elements of the cytoskeleton interact intimately and communicate bidirectionally with cellular
membranes. Such interactions are critical for a host of cellular processes. Here we focus on …

Many viruses that enter cells by clathrin-dependent endocytosis are significantly larger than
the dimensions of a typical clathrin-coated vesicle. The mechanisms by which viruses co-opt …

Wednesday, March 4, 2009 569a that deform the underlying membrane by progressive
recruitment of clathrin, adaptors and other regulatory proteins. They ultimately close off and …