Preconditioned and genetically modified stem cells for myocardial infarction treatment

K Raziyeva, A Smagulova, Y Kim, S Smagul… - International journal of …, 2020 - mdpi.com
Ischemic heart disease and myocardial infarction remain leading causes of mortality
worldwide. Existing myocardial infarction treatments are incapable of fully repairing and …

The dual role of mesenchymal stem cells in apoptosis regulation

Z Chen, X Xia, M Yao, Y Yang, X Ao, Z Zhang… - Cell Death & …, 2024 - nature.com
Mesenchymal stem cells (MSCs) are widely distributed pluripotent stem cells with powerful
immunomodulatory capacity. MSCs transplantation therapy (MSCT) is widely used in the …

CRISPR/Cas9-mediated knockout of Lcn2 in human breast cancer cell line MDA-MB-231 ameliorates erastin-mediated ferroptosis and increases cisplatin vulnerability

MR Valashedi, AM Roushandeh, K Tomita… - Life sciences, 2022 - Elsevier
Abstract Aims Lipocalin 2 (Lcn2) is an antioxidant-related protein upregulated in various
cellular stress conditions, especially cancer. In this study, we abrogated Lcn2 expression in …

Preconditioning of mesenchymal stem cells with ghrelin exerts superior cardioprotection in aged heart through boosting mitochondrial function and autophagy flux

L Sun, W Zhang - European Journal of Pharmacology, 2021 - Elsevier
Application of mesenchymal stem cells (MSCs) is considered as a promising cell-based
therapy to induce cardioprotection against ischemia-reperfusion (IR) injury. Preconditioning …

Taming of Covid-19: potential and emerging application of mesenchymal stem cells

N Najafi-Ghalehlou, MH Roudkenar, HZ Langerodi… - Cytotechnology, 2021 - Springer
Abstract Coronavirus Disease 2019 (COVID-19) caused by the Severe Acute Respiratory
Syndrome Coronavirus 2 (SARS-CoV-2) has turned out to cause a pandemic, with a sky …

Plumping up a Cushion of Human Biowaste in Regenerative Medicine: Novel Insights into a State-of-the-Art Reserve Arsenal

N Najafi-Ghalehlou, A Feizkhah, M Mobayen… - Stem Cell Reviews and …, 2022 - Springer
Major breakthroughs and disruptive methods in disease treatment today owe their thanks to
our inch by inch developing conception of the infinitive aspects of medicine since the very …

[HTML][HTML] A bioinformatics approach to identifying the biomarkers and pathogenesis of major depressive disorder combined with acute myocardial infarction

C Yu, F Zhang, L Zhang, J Li, S Tang, X Li… - American Journal of …, 2023 - ncbi.nlm.nih.gov
This study investigated the pathogenesis of major depressive disorder (MDD) and acute
myocardial infarction (AMI) using bioinformatics. We analyzed MDD and AMI (MDD-AMI) …

[HTML][HTML] Combination therapy of metadichol nanogel and lipocalin-2 engineered mesenchymal stem cells improve wound healing in rat model of excision injury

Z Pourmohammadi-Bejarpasi, R Sabzevari… - Advanced …, 2022 - ncbi.nlm.nih.gov
Purpose: Currently, several disorders including burns, trauma, excisional and diabetic
wounds, and bedsores threaten the human health. Application of mesenchymal stem cells …

Glutathione safeguards TET‐dependent DNA demethylation and is critical for the acquisition of totipotency and pluripotency during preimplantation development

J Liu, M Chu, J Zhang, J He, Q Yang, L Tao… - The FASEB …, 2024 - Wiley Online Library
During early development, both genome‐wide epigenetic reprogramming and metabolic
remodeling are hallmark changes of normal embryogenesis. However, little is known about …

[HTML][HTML] Time to Revise the Medical Students' Educational Curriculum: Focus on New Therapeutic Strategies as Regenerative Medicine in Neurological Disorders

C Bamshad, A Saberi, S Rezaei… - Iranian Journal of …, 2022 - irjns.org
Stem cells are non-specific cells, which are able to differentiate into specialized cells that
make up different tissues in the body. This strong ability to proliferate and differentiate into a …