The ability to respond to injury with tissue repair is a fundamental property of all multicellular
organisms. The extracellular matrix (ECM), composed of fibrillar collagens as well as a …

In this study we present an image analysis methodology capable of quantifying
morphological changes in tissue collagen fibril organization caused by pathological …

There are many factors of methodological origin that influence the measurement of optical
properties of the entire circulatory system which consists of blood as the basic component …

Over the past years fast label-free nonlinear imaging modalities providing molecular contrast
of endogenous disease markers with subcellular spatial resolution have been emerged …

The past years have seen increasing interest in nonlinear optical microscopic imaging
approaches for the investigation of diseases due to the method's unique capabilities of deep …

Structural proteins like collagen and elastin are major constituents of the extracellular matrix
(ECM). ECM degradation and remodeling in diseases significantly impact the …

Cerebral aneurysms are abnormal focal dilatations of arterial vessel walls with pathological
vessel structure alterations. Sudden rupture can lead to a subarachnoid hemorrhage, which …

Recent progress regarding shortwave-infrared (SWIR) molecular imaging technology has
inspired another modality of noninvasive diagnosis for early breast cancer detection in …

Background During atherosclerosis, the narrowing of the arterial lumen is observed through
the accumulation of bio compounds and the formation of plaque within artery walls. A non …

Currently, the targeted treatment of tumor based on the tumor microenvironment is newly
developed. Blood vessels are the key parts in the tumor microenvironment, which is taken as …