Rac and Cdc42 are small GTPases that have been linked to multiple human cancers and
are implicated in epithelial to mesenchymal transition, cell-cycle progression …

Malignant carcinomas are often characterized by metastasis, the movement of carcinoma
cells from a primary site to colonize distant organs. For metastasis to occur, carcinoma cells …

Cell movement has essential functions in development, immunity, and cancer. Various cell
migration patterns have been reported, but no general rule has emerged so far. Here, we …

Fasting triggers diverse physiological adaptations including increases in circulating fatty
acids and mitochondrial respiration to facilitate organismal survival. The mechanisms driving …

Coronavirus disease 2019 is a kind of viral pneumonia caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2). However, the mechanism whereby SARS-CoV-2 …

Plasma membrane tension regulates many key cellular processes. It is modulated by, and
can modulate, membrane trafficking. However, the cellular pathway (s) involved in this …

RHO GTPases are a subfamily of the RAS superfamily of proteins, which are highly
conserved in eukaryotic species and have important biological functions, including actin …

Mammalian cells mostly rely on extracellular molecules to transfer signals to other cells.
However, in stress conditions, more robust mechanisms might be necessary to facilitate cell …

The progress we have made in understanding Alzheimer's disease (AD) pathogenesis has
led to the identification of several novel pathways and potential therapeutic targets. Rho …

The maintenance of whole-body glucose homeostasis is critical for survival, and is
controlled by the coordination of multiple organs and endocrine systems. Pancreatic islet β …