Male germ cells undergo an extreme but fascinating process of chromatin remodeling that
begins in the testis during the last phase of spermatogenesis and continues through …

The genome of mammalian sperm is largely packaged by sperm-specific proteins termed
protamines. The presence of some residual nucleosomes has, however, emerged as a …

Bromodomains are critical components of many chromatin modifying/remodelling proteins
and are emerging therapeutic targets, yet how they interact with nucleosomes, rather than …

Sirtuins are NAD+-dependent deacylases that regulate numerous biological processes in
response to the environment. SirT1 is the mammalian ortholog of yeast Sir2, and is involved …

Mammalian spermiogenesis is of considerable biological interest especially due to the
unique chromatin remodeling events that take place during spermatid maturation. Here, we …

It is hard to fathom that one of the most highly differentiated cells in the body, the
spermatozoon, spends over half of its developmental life without the capacity for nuclear …

Objective Sperm morphology plays an important role in infertility, especially in cases of
defects in the heads of spermatozoa. Tapered-head or elongated-head spermatozoa are …

The changes in chromatin organization that occur as mammalian spermatocytes differentiate
into mature sperm are among the most extreme that have been observed in biology. The …

Here we demonstrated that pillar [5] arenes with counterions I− and Cl− show the ability to
plasmid compactization and increasing bacterial transformation efficiently. Pillar [5] arenes …

In the previous study, we unraveled the unique “erasure strategy” during the mouse
spermiogenesis. Chromatin associated proteins sequentially disassociated from the …