Traumatic brain injury and peripheral immune suppression: primer and prospectus

J Hazeldine, JM Lord, A Belli - Frontiers in neurology, 2015 - frontiersin.org
Nosocomial infections are a common occurrence in patients following traumatic brain injury
(TBI) and are associated with an increased risk of mortality, longer length of hospital stay …

Immune modulation after traumatic brain injury

M Bouras, K Asehnoune, A Roquilly - Frontiers in Medicine, 2022 - frontiersin.org
Traumatic brain injury (TBI) induces instant activation of innate immunity in brain tissue,
followed by a systematization of the inflammatory response. The subsequent response …

Biomarkers predicting sepsis in polytrauma patients: Current evidence

V Ciriello, S Gudipati, PZ Stavrou, NK Kanakaris… - Injury, 2013 - Elsevier
Introduction Major trauma still represents one of the leading causes of death in the first four
decades of life. Septic complications represent the predominant causes of late death (45 …

Systemic immune response in young and elderly patients after traumatic brain injury

M Magatti, F Pischiutta, F Ortolano, A Pasotti… - Immunity & …, 2023 - Springer
Background Traumatic brain injury (TBI) is a leading cause of death and long-term disability
worldwide. In addition to primary brain damage, systemic immune alterations occur, with …

[HTML][HTML] Single Versus Repetitive Traumatic Brain Injury: Current Knowledge on the Chronic Outcomes, Neuropathology and the Role of TDP-43 Proteinopathy

T Janković, K Pilipović - Experimental neurobiology, 2023 - ncbi.nlm.nih.gov
Traumatic brain injury (TBI) is one of the most important causes of death and disability in
adults and thus an important public health problem. Following TBI, secondary …

Dysregulated brain-gut axis in the setting of traumatic brain injury: review of mechanisms and anti-inflammatory pharmacotherapies

MG El Baassiri, Z Raouf, S Badin, A Escobosa… - Journal of …, 2024 - Springer
Traumatic brain injury (TBI) is a chronic and debilitating disease, associated with a high risk
of psychiatric and neurodegenerative diseases. Despite significant advancements in …

Particularities of hand and wrist complex injuries in polytrauma management

D Ciclamini, B Panero, P Titolo, P Tos, B Battiston - Injury, 2014 - Elsevier
Hand and wrist lesions are relatively common in polytraumatised patients. These subjects
sustain a wide range of potential life-threatening conditions and hand and wrist injuries …

Different perforin expression in peripheral blood and prostate tissue in patients with benign prostatic hyperplasia and prostate cancer

VS Tokmadžić, MI Tomaš, S Sotošek… - Scandinavian …, 2011 - Wiley Online Library
Perforin (P) is a prototypical cytotoxic molecule involved in cell‐mediated immunity against
various pathogens, alloantigens and particularly different tumours. The purpose of this study …

Decreased levels of perforin-positive lymphocytes are associated with posttraumatic complications in patients with major trauma

R Hua, Y Zhang, F Chen, Z Zhou, X Li, B Shao, S Wang… - Injury, 2014 - Elsevier
Objective Posttraumatic immune disorder can cause complications including systemic
inflammatory response syndrome (SIRS) and multiple-organ dysfunction syndrome (MODS) …

[HTML][HTML] Postoperative regional analgesia is effective in preserving perforin-expressing lymphocytes in patients after total knee replacement

SV Brumnjak, I Rakovac, DP Kinkela… - … Medical Journal of …, 2018 - ncbi.nlm.nih.gov
Background Pain and surgical stress cause a pro-inflammatory response followed by
downregulation of the immune response, which can increase the incidence of postoperative …