The past few years has witnessed a booming market of protein and peptide drugs, owing to
their superior efficiency and biocompatibility. Parenteral route is the most commonly …

Highlights•The human proteasome is the second largest drug target class.•Few prototypic
proteases are standard tools for the discovery of novel inhibitors.•Peptide protease inhibitors …

Chemical synthesis is a well‐established method for the preparation in the research
laboratory of multiple‐tens‐of‐milligram amounts of correctly folded, high purity protein …

Chemical synthesis of proteins containing up to 300 amino acids may cover 30%–50% of all
the proteins encountered in biomedical studies and may provide an alternate approach to …

Enzymes are widely used in industrial and pharmaceutical applications, but their activities
often decrease rapidly under harsh environmental conditions such as heat, organic solvents …

SARS-CoV-2 is a corona virus that has been the cause for one of the deadliest pandemics of
history, started since 2019. Suppressing the activity of the critical enzymes in the SARS-CoV …

The problem of antibiotic resistance (AR) in pathogenic bacteria due to the massive use of
antibiotics in animals is an underestimated issue. Finding alternatives to reduce or eliminate …

Cell targeting has been considered an important strategy in diagnostic and therapeutic
applications. Among different targeting units, peptides have emerged for their ability to bind …

We previously reported that Lys175 in the region of the active site of chymotrypsin (Csin)
could be site-selectively modified by using an N-hydroxy succinimide (NHS) ester of the …

Covalent cross-linking of biomolecules can be useful in pursuit of tissue targeting or dual
targeting of two receptors on cell surfaces for avidity effects. Long linkers (> 10 kDa) can be …