Recent update on the heterogeneity of the Alzheimer's disease spectrum

KA Jellinger - Journal of Neural Transmission, 2022 - Springer
Abstract Alzheimer's disease (AD), the most common form of dementia worldwide, is a mixed
proteinopathy (β-amyloid, tau and other proteins). Classically defined as a …

Ethical issues when using digital biomarkers and artificial intelligence for the early detection of dementia

E Ford, R Milne, K Curlewis - Wiley Interdisciplinary Reviews …, 2023 - Wiley Online Library
Dementia poses a growing challenge for health services but remains stigmatized and under‐
recognized. Digital technologies to aid the earlier detection of dementia are approaching …

Caution,“normal” BMI: health risks associated with potentially masked individual underweight—EPMA Position Paper 2021

O Golubnitschaja, A Liskova, L Koklesova, M Samec… - EPMA Journal, 2021 - Springer
An increasing interest in a healthy lifestyle raises questions about optimal body weight.
Evidently, it should be clearly discriminated between the standardised “normal” body weight …

The immune system as a therapeutic target for Alzheimer's disease

T Zieneldien, J Kim, D Sawmiller, C Cao - Life, 2022 - mdpi.com
Alzheimer's disease (AD) is a heterogeneous neurodegenerative disorder and is the most
common cause of dementia. Furthermore, aging is considered the most critical risk factor for …

The Alzheimer's Disease Neuroimaging Initiative in the era of Alzheimer's disease treatment: A review of ADNI studies from 2021 to 2022

DP Veitch, MW Weiner, M Miller, PS Aisen… - Alzheimer's & …, 2024 - Wiley Online Library
Abstract The Alzheimer's Disease Neuroimaging Initiative (ADNI) aims to improve
Alzheimer's disease (AD) clinical trials. Since 2006, ADNI has shared clinical, neuroimaging …

ADataViewer: exploring semantically harmonized Alzheimer's disease cohort datasets

Y Salimi, D Domingo-Fernández… - Alzheimer's Research & …, 2022 - Springer
Abstract Background Currently, Alzheimer's disease (AD) cohort datasets are difficult to find
and lack across-cohort interoperability, and the actual content of publicly available datasets …

Data and sample sharing as an enabler for large-scale biomarker research and development: the EPND perspective

N Bose, AJ Brookes, P Scordis, PJ Visser - Frontiers in Neurology, 2022 - frontiersin.org
Biomarker discovery, development, and validation are reliant on large-scale analyses of
high-quality samples and data. Currently, significant quantities of data and samples have …

[HTML][HTML] Transferability of Alzheimer's disease progression subtypes to an independent population cohort

H Chen, A Young, NP Oxtoby, F Barkhof, DC Alexander… - NeuroImage, 2023 - Elsevier
In the past, methods to subtype or biotype patients using brain imaging data have been
developed. However, it is unclear whether and how these trained machine learning models …

Characteristics of amnestic patients with hypometabolism patterns suggestive of Lewy body pathology

J Silva-Rodríguez, MA Labrador-Espinosa, A Moscoso… - Brain, 2023 - academic.oup.com
A clinical diagnosis of Alzheimer's disease dementia (ADD) encompasses considerable
pathological and clinical heterogeneity. While Alzheimer's disease patients typically show a …

Semantic harmonization of Alzheimer's disease datasets using AD-Mapper

P Wegner, H Balabin, MC Ay… - Journal of …, 2023 - content.iospress.com
Background: Despite numerous past endeavors for the semantic harmonization of
Alzheimer's disease (AD) cohort studies, an automatic tool has yet to be developed …