Many psychiatric disorders, despite their specific characteristics, share deficits in the
cognitive domain including executive functions, emotional control and memory. However …

In the brain, neuronal gene expression is dynamically changed in response to neuronal
activity. In particular, the expression of immediate-early genes (IEGs) such as egr-1, c-fos …

Retrosplenial cortex is a region within the posterior neocortical system, heavily
interconnected with an array of brain networks, both cortical and subcortical, that is …

The ability to recognize a previously experienced stimulus is supported by two processes:
recollection of the stimulus in the context of other information associated with the …

The amnestic effects of hippocampal lesions are well documented, leading to numerous
memory-based theories of hippocampal function. It is debatable, however, whether any one …

The hallmark of medial temporal lobe amnesia is a loss of episodic memory such that
patients fail to remember new events that are set in an autobiographical context (an …

The c-fos gene was first described as a proto-oncogene responsible for the induction of
bone tumors. A few decades ago, activation of the protein product c-fos was reported in the …

Neuronal immediate-early gene (IEG) expression is regulated by synaptic activity and plays
an important role in the neuroplastic mechanisms critical to memory consolidation. IEGs can …

Here we describe a model of medial temporal lobe organization in which parallel “what” and
“where” processing streams converge within the hippocampus to represent events in the …

A review of medial temporal lobe connections reveals three distinct groupings of
hippocampal efferents. These efferent systems and their putative memory functions are:(1) …