As the key cellular effectors of adaptive immunity, T and B lymphocytes utilize specialized
receptors to recognize, respond to, and neutralize a diverse array of extrinsic threats. These …

Clones are the fundamental building blocks of immune repertoires. The number of different
clones relates to the diversity of the repertoire, whereas their size and sequence diversity …

Motivation: The diversity of the immune repertoire is initially generated by random
rearrangements of the receptor gene during early T and B cell development. Rearrangement …

Background Clonal expansion of B lymphocytes coupled with somatic mutation and antigen
selection allow the mammalian humoral immune system to generate highly specific …

The process of antibody ontogeny typically improves affinity, on-rate, and thermostability,
narrows polyspecificity, and rigidifies the combining site to the conformer optimal for binding …

In cancer and autoimmune diseases, immunoglobulins with a specific molecular signature
that could potentially be used as diagnostic or prognostic markers are released into body …

Genetically modified non-human animals and methods and compositions for making and
using them are provided, wherein the genetic modification comprises (a) a deletion in an …

Identifying the germline genes involved in immunoglobulin rearrangements is an essential
first step in the analysis of antibody repertoires. Based on our prior work in analysing diverse …

Motivation: Immunoglobulin heavy chain genes are formed by recombination of genes
randomly selected from sets of IGHV, IGHD and IGHJ genes. Utilities have been developed …

Background The genes that produce antibodies and the immune receptors expressed on
lymphocytes are not germline encoded; rather, they are somatically generated in each …