Dysregulation in lipid metabolism is among the most prominent metabolic alterations in
cancer. Cancer cells harness lipid metabolism to obtain energy, components for biological …

Acetyl-CoA carboxylases (ACCs) are enzymes that catalyze the carboxylation of acetyl-CoA
to produce malonyl-CoA. In mammals, ACC1 and ACC2 are two members of ACCs. ACC1 …

Current standard-of-care (SOC) therapy for breast cancer includes targeted therapies such
as endocrine therapy for estrogen receptor-alpha (ERα) positive; anti-HER2 monoclonal …

Background Abnormal expression of protein tyrosine phosphatases (PTPs) has been
reported to be a crucial cause of cancer. As a member of PTPs, protein tyrosine …

The breast and ovarian cancer susceptibility gene (BRCA1) is a tumor suppressor whose
mutation has been associated with the development of breast, ovarian and, probably, other …

Hyperglycaemia is a common metabolic alteration associated with breast cancer risk and
progression. We have previously reported that BRCA1 restrains metabolic activity and …

Breast cancer is the most prevalent cancer in women. Metabolic abnormalities, particularly
increased lipid synthesis and uptake, impact the onset and progression of the disease …

Gynaecological cancers are among the leading causes of cancer-related death among
women worldwide. Cancer cells undergo metabolic reprogramming to sustain the …

Metabolism affects the development, progression, and prognosis of various cancers,
including breast cancer (BC). Our aim was to develop a metabolism-related long non-coding …

Triple negative breast cancer (TNBC) represents a highly heterogeneous group of breast
cancers, lacking expression of the estrogen (ER) and progesterone (PR) receptors, and …