Klotho is a novel renoprotective anti-aging protein available in membrane-bound or soluble
form. Klotho is expressed in brain, pancreas, and other solid organs but shows highest …

Alzheimer's disease (AD) is an age-associated neurodegenerative disease; it is the most
common cause of senile dementia. Klotho, a single-pass transmembrane protein primarily …

Autophagy has dual effects in human diseases: appropriate autophagy may protect cells
from stress, while excessive autophagy may cause cell death. Additionally, close …

Immunosenescence in monocytes has been shown to be associated with several
biochemical and functional changes, including development of senescence-associated …

Klotho is an antiaging protein that has multiple functions. The purpose of this study is to
investigate whether soluble klotho plays a role in cellular stress response pathways. We …

Klotho is one of a number of well-known longevity-associated genes. Its depletion in aging
or disease may promote several neuropathologies associated with the central nervous …

Neuroinflammation is defined as the activation of the brain's innate immune system in
response to an inflammatory challenge and is considered to be a prominent feature of …

Klotho gene was originally recognized as a putative aging-suppressor and its prominent age-
regulating effects are mostly attributed to the modulation of mineral homeostasis in the …

Drug-loaded, brain-targeted nanocarriers could be a promising tool in overcoming the
challenges associated with Alzheimer's disease therapy. These nanocargoes are …

Klotho is one of a number of well-known longevity-associated genes. Its depletion in aging
or disease may promote several neuropathologies associated with the central nervous …