The secretion profile of mesenchymal stem cells and potential applications in treating human diseases
Y Han, J Yang, J Fang, Y Zhou, E Candi… - … and Targeted Therapy, 2022 - nature.com
Mesenchymal stromal/stem cells (MSCs) possess multi-lineage differentiation and self-
renewal potentials. MSCs-based therapies have been widely utilized for the treatment of …
renewal potentials. MSCs-based therapies have been widely utilized for the treatment of …
Reciprocal regulation of mesenchymal stem cells and immune responses
Mesenchymal stem/stromal cells (MSCs) exist in almost all tissues and participate in tissue
regeneration and homeostasis. In-vitro-expanded MSCs are employed as therapeutics for …
regeneration and homeostasis. In-vitro-expanded MSCs are employed as therapeutics for …
[HTML][HTML] Mesenchymal stromal cells: putative microenvironmental modulators become cell therapy
M Krampera, K Le Blanc - Cell stem cell, 2021 - cell.com
An exceptional safety profile has been shown in a large number of cell therapy clinical trials
that use mesenchymal stromal cells (MSCs). However, reliable potency assays are still …
that use mesenchymal stromal cells (MSCs). However, reliable potency assays are still …
Shattering barriers toward clinically meaningful MSC therapies
More than 1050 clinical trials are registered at FDA. gov that explore multipotent
mesenchymal stromal cells (MSCs) for nearly every clinical application imaginable …
mesenchymal stromal cells (MSCs) for nearly every clinical application imaginable …
Immune modulation by mesenchymal stem cells
W Jiang, J Xu - Cell proliferation, 2020 - Wiley Online Library
Mesenchymal stem cells (MSCs) can be derived from various adult tissues with multipotent
and self‐renewal abilities. The characteristics of presenting no major ethical concerns …
and self‐renewal abilities. The characteristics of presenting no major ethical concerns …
Mesenchymal stromal cells: clinical challenges and therapeutic opportunities
J Galipeau, L Sensébé - Cell stem cell, 2018 - cell.com
Mesenchymal stromal cells (MSCs) have been the subject of clinical trials for more than a
generation, and the outcomes of advanced clinical trials have fallen short of expectations …
generation, and the outcomes of advanced clinical trials have fallen short of expectations …
Production, safety and efficacy of iPSC-derived mesenchymal stromal cells in acute steroid-resistant graft versus host disease: a phase I, multicenter, open-label, dose …
AJC Bloor, A Patel, JE Griffin, MH Gilleece, R Radia… - Nature medicine, 2020 - nature.com
The therapeutic potential of donor-derived mesenchymal stromal cells (MSCs) has been
investigated in diverse diseases, including steroid-resistant acute graft versus host disease …
investigated in diverse diseases, including steroid-resistant acute graft versus host disease …
Priming approaches to improve the efficacy of mesenchymal stromal cell-based therapies
NC Noronha, A Mizukami, C Caliári-Oliveira… - Stem cell research & …, 2019 - Springer
Multipotent mesenchymal stromal cells (MSC) have been widely explored for cell-based
therapy of immune-mediated, inflammatory, and degenerative diseases, due to their …
therapy of immune-mediated, inflammatory, and degenerative diseases, due to their …
Immunoregulatory mechanisms of mesenchymal stem and stromal cells in inflammatory diseases
Mesenchymal stem cells (MSCs; also referred to as mesenchymal stromal cells) have
attracted much attention for their ability to regulate inflammatory processes. Their therapeutic …
attracted much attention for their ability to regulate inflammatory processes. Their therapeutic …
Biological functions of mesenchymal stem cells and clinical implications
Mesenchymal stem cells (MSCs) are isolated from multiple biological tissues—adult bone
marrow and adipose tissues and neonatal tissues such as umbilical cord and placenta. In …
marrow and adipose tissues and neonatal tissues such as umbilical cord and placenta. In …