Mutations in the vacuolar protein sorting 35 ortholog (VPS35) gene encoding a core
component of the retromer complex, have recently emerged as a new cause of late-onset …

Introduction Variants in the leucine-rich repeat kinase 2 gene (LRRK2) are risk factors for
Parkinson's disease (PD), but their prevalence varies geographically, reflecting the locations …

Parkinson's disease (PD) is a genetically heterogeneous disorder and new putative disease
genes are discovered constantly. Therefore, whole‐exome sequencing could be an efficient …

Biallelic Parkin (PRKN) mutations cause autosomal recessive Parkinson's disease (PD);
however, the role of monoallelic PRKN mutations as a risk factor for PD remains unclear. We …

Abstract Background The Iberian Peninsula stands out as having variable levels of
population admixture and isolation, making Spain an interesting setting for studying the …

Common variants and risk factors related to familial and sporadic cases of Parkinson's
disease (PD) in diverse populations have been identified at numerous genomic loci. In this …

Mutations in the gene encoding the lysosomal enzyme acid β-glucosidase (GBA) are
responsible for Gaucher disease and represent the main genetic risk factor for developing …

Highlights•In the endosomal network retromer retrieves cargo away from the degradative
pathway.•Retromer dysfunction has been implicated in Parkinson's disease through different …

Introduction Both recessive and dominant genetic forms of Parkinson's disease have been
described. The aim of this study was to assess the contribution of several genes to the …

Leucine-rich repeat kinase 2 (LRRK2) is a large protein kinase that physiologically
phosphorylates and regulates the function of several Rab proteins. LRRK2 is genetically …