Red blood cells (RBCs), which constitute the most abundant cell type in the body, come in
two distinct flavors-primitive and definitive. Definitive RBCs in mammals circulate as smaller …

The Krüppel-like factor (KLF) family of transcription factors regulates diverse biological
processes that include proliferation, differentiation, growth, development, survival, and …

Abstract The Kruppel-Like Factor family of regulatory proteins, which has 18 members, is
transcription factors. This family contains zinc finger proteins, regulates the activation and …

The cellular events that lead to terminal erythroid differentiation rely on the controlled
interplay of extra-and intracellular regulatory factors. Their downstream effects are highly …

Krüppel-like factors (KLFs) are a family of zinc-finger transcription factors that are found in
many species. Recent studies have shown that KLFs play a fundamental role in regulating …

The transcription factor Klf4 has demonstrated activity in the reprogramming of somatic cells
to a pluripotent state, but the molecular mechanism of this process remains unknown. It is …

The study of embryonic development in several different model systems, as well as in
cultured human embryonic stem cells, continues to provide important insights into the …

Update on fetal hemoglobin gene regulation in hemoglobinopat... : Current Opinion in
Pediatrics Update on fetal hemoglobin gene regulation in hemoglobinopathies : Current …

Krüppel-like factor 1 (KLF1) plays a crucial role in erythropoiesis. In-depth studies conducted
on mice and humans have highlighted its importance in erythroid lineage commitment …

Precise transcriptional control of developmental stage-specific expression and switching of α-
and β-globin genes is significantly important to understand the general principles controlling …