Cilia play many essential roles in fluid transport and cellular locomotion, and as sensory
hubs for a variety of signal transduction pathways. Despite having a conserved basic …

Defects in the function of cellular organelles such as peroxisomes, lysosomes and
mitochondria are well-known causes of human diseases. Recently, another organelle has …

Primary cilia are hair-like organelles and play crucial roles in vertebrate development,
organogenesis, health, and many genetic disorders. A primary cilium is a mechano-sensory …

Cilia are complex structures that have garnered interest because of their roles in vertebrate
development and their involvement in human genetic disorders. In contrast to multicellular …

Several studies have linked cilia and Hedgehog signaling, but the precise roles of ciliary
proteins in signal transduction remain enigmatic. Here we describe a mouse mutation …

Cilia and flagella have attracted tremendous attention in recent years as research
demonstrated crucial roles for these organelles in coordinating a number of physiologically …

Although cardiac abnormalities have been observed in a growing class of human disorders
caused by defective primary cilia, the function of cilia in the heart remains an underexplored …

Although first described as early as 1898 and long considered a vestigial organelle of little
functional importance, the primary cilium has become one of the hottest research topics in …

It has been proposed that ciliated cells that produce a leftward fluid flow mediate left-right
patterning in many vertebrate embryos. The cilia on these cells combine features of primary …

Morphological asymmetry is a common feature of animal body plans, from shell coiling in
snails to organ placement in humans. The signaling protein Nodal is key for determining this …