Discovery of the myogenic regulatory factor family of transcription factors MYF5, MYOD,
Myogenin and MRF4 was a seminal step in understanding specification of the skeletal …

Adult skeletal muscle in mammals is a stable tissue under normal circumstances but has
remarkable ability to repair after injury. Skeletal muscle regeneration is a highly orchestrated …

Background A longstanding goal in regenerative medicine is to reconstitute functional tissus
or organs after injury or disease. Attention has focused on the identification and relative …

Despite a massive body of knowledge which has been produced related to the mechanisms
guiding muscle regeneration, great interest still moves the scientific community toward the …

Muscle regeneration requires the coordinated interaction of multiple cell types. Satellite cells
have been implicated as the primary stem cell responsible for regenerating muscle, yet the …

Cultured muscle tissue‐based protein products, also known as cultured meat, are produced
through in vitro myogenesis involving muscle stem cell culture and differentiation, and …

The ability to maintain quiescence is critical for the long-term maintenance of a functional
stem cell pool. To date, the epigenetic and transcriptional characteristics of quiescent stem …

Satellite cells are adult myogenic stem cells that repair damaged muscle. The enduring
capacity for muscle regeneration requires efficient satellite cell expansion after injury, their …

Prenatal and postnatal myogenesis share many cellular and molecular aspects. Myogenic
regulatory factors are basic Helix-Loop-Helix transcription factors that indispensably …

Distinct cell populations with regenerative capacity have been reported to contribute to
myofibres after skeletal muscle injury, including non-satellite cells as well as myogenic …