Nerve growth factor (NGF) is a neurotrophic protein essential for the growth, differentiation,
and survival of sympathetic and sensory afferent neurons during development. A substantial …

The highly disagreeable sensation of pain results from an extraordinarily complex and
interactive series of mechanisms integrated at all levels of the neuroaxis, from the periphery …

▪ Abstract Nerve growth factor (NGF) was discovered 50 years ago as a molecule that
promoted the survival and differentiation of sensory and sympathetic neurons. Its roles in …

Topographical guidance and chemotaxis are crucial factors for peripheral nerve
regeneration. This study describes the preparation of highly aligned poly (ε …

▪ Abstract The guidance of axons during the establishment of the nervous system is
mediated by a variety of extracellular cues that govern cytoskeletal dynamics in axonal …

Recent imaging studies show that the formation of neural connections in the central nervous
system is a highly dynamic process. The iterative formation and elimination of synapses and …

Although the requirement of neurotrophins for the prevention of cell death in the peripheral
nervous system is well established, their physiological involvement in nerve growth is still …

Neurotrophins regulate neuronal cell survival and synaptic plasticity through activation of Trk
receptor tyrosine kinases. Binding of neurotrophins to Trk receptors results in receptor …

The precise patterns of neuronal assembly during development determine all functional
outputs of a nervous system; these may range from simple reflexes to learning, memory …

Previous attempts to promote regeneration after spinal cord injury have succeeded in
stimulating axonal growth into or around lesion sites but rarely beyond them. We tested …