The first 2 years of the COVID-19 pandemic were mainly characterized by recurrent
mutations of SARS-CoV-2 Spike protein at residues K417, L452, E484, N501 and P681 …

Molnupiravir, an antiviral medication widely used against severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), acts by inducing mutations in the virus genome during …

Over three years' pandemic of 2019 novel coronavirus disease (COVID-19), multiple
variants and novel subvariants have emerged successively, outcompeted earlier variants …

A major challenge in understanding SARS-CoV-2 evolution is interpreting the antigenic and
functional effects of emerging mutations in the viral spike protein. Here, we describe a deep …

Abstract Knowledge of the fitness effects of mutations to SARS-CoV-2 can inform
assessment of new variants, design of therapeutics resistant to escape, and understanding …

The nucleocapsid protein of severe acute respiratory syndrome coronavirus 2 encapsidates
the viral genome and is essential for viral function. The central disordered domain comprises …

Genetic diversity is a hallmark of RNA viruses and the basis for their evolutionary success.
Taking advantage of the uniquely large genomic database of SARS-CoV-2, we examine the …

The COVID-19 pandemic has been characterised by sequential variant-specific waves
shaped by viral, individual human and population factors. SARS-CoV-2 variants are defined …

Molecular mimicry of short linear interaction motifs has emerged as a key mechanism for
viral proteins binding host domains and hijacking host cell processes. Here, we examine the …

Human activities are accelerating rates of biological invasions and climate-driven range
expansions globally, yet we understand little of how genomic processes facilitate the …