Phytochemical-based nanomedicine for targeting tumor microenvironment and inhibiting cancer chemoresistance: recent advances and pharmacological insights

P Sa, P Mohapatra, SS Swain, A Khuntia… - Molecular …, 2023 - ACS Publications
Cancer remains the leading cause of death and rapidly evolving disease worldwide. The
understanding of disease pathophysiology has improved through advanced research …

Microbiota-derived natural products targeting cancer stem cells: inside the gut pharma factory

V Artusa, L Calabrone, L Mortara, F Peri… - International Journal of …, 2023 - mdpi.com
Cancer stem cells (CSCs) have drawn much attention as important tumour-initiating cells
that may also be crucial for recurrence after chemotherapy. Although the activity of CSCs in …

Serving up health: How phytochemicals transform food into medicine in the battle against cancer

E Sharma, M Tewari, P Sati, I Sharma, DC Attri… - Food …, 2024 - Wiley Online Library
The escalating global cancer burden underscores the urgent need for more effective
therapeutic strategies. Phytochemicals, naturally occurring compounds in plants, have …

Hovenia dulcis Suppresses the Growth of Huh7-Derived Liver Cancer Stem Cells by Inducing Necroptosis and Apoptosis and Blocking c-MET Signaling

M Kwon, HJ Jung - Cells, 2023 - mdpi.com
Liver cancer stem cells (LCSCs) contribute to the initiation, metastasis, treatment resistance,
and recurrence of hepatocellular carcinoma (HCC). Therefore, exploring potential …

Evidence of potential plant-derived compounds with anticancer effects on lung cancer: Clinical and molecular pharmacology approaches

M Sukprasansap, P Chanvorachote - Anticancer Research, 2022 - ar.iiarjournals.org
The effects of plant-derived active compounds on cancer cells have been intensively
investigated, leading to the possibility of dietary-based cancer prevention regimens and …

[HTML][HTML] The HHEX-ABI2/SLC17A9 axis induces cancer stem cell-like properties and tumorigenesis in HCC

H Li, J Liu, J Lai, X Su, X Wang, J Cao… - Journal of …, 2024 - ncbi.nlm.nih.gov
Accumulating evidence indicated that HHEX participated in the initiation and development of
several cancers, but the potential roles and mechanisms of HHEX in hepatocellular …

[HTML][HTML] Phytochemicals in Drug Discovery—A Confluence of Tradition and Innovation

P Chihomvu, A Ganesan, S Gibbons… - International Journal of …, 2024 - mdpi.com
Phytochemicals have a long and successful history in drug discovery. With recent
advancements in analytical techniques and methodologies, discovering bioactive leads from …

Natural compounds as a potential modifier of stem cells renewal: Comparative analysis

A Mishra, Y Pathak, SK Mishra, H Prakash… - European Journal of …, 2023 - Elsevier
Cancer stem cells (CSCs) are indispensable for development, progression, drug resistance,
and tumor metastasis. Current cancer-directed interventions target targeting rapidly dividing …

Plant-based drugs: the potential novel therapeutic intervention against cancer stemness and metastasis

VB Liju, S Martin, LR Nath… - Frontiers in …, 2023 - frontiersin.org
Cancer is the second most common fatal disease leading to death worldwide. Metastatic
growth in distant organs is the main reason for increased cancer mortality (Steinbichler et al …

[HTML][HTML] Cytotoxicity Activity, Metabolite Profiling, and Isolation Compound from Crude Hexane Extract of Cleome rutidospermae

B Yasir, A Rahim, S Lallo, Y Saito… - Asian Pacific Journal …, 2023 - ncbi.nlm.nih.gov
Objective: This study isolated the chemical compounds and evaluated the cytotoxic activity
of the crude hexane extract of Cleome rutidospermae herb (CRH). Methods: The isolate was …