Exosomes: multifaceted messengers in atherosclerosis

H Wang, Y Xie, AM Salvador, Z Zhang, K Chen… - Current Atherosclerosis …, 2020 - Springer
Abstract Purpose of Review Atherosclerosis (AS) is a chronic inflammatory disease that
contributes to the development of coronary artery disease, which has become a leading …

Akap12 signaling complex: Impacts of compartmentalizing camp‐dependent signaling pathways in the heart and various signaling systems

H Qasim, BK McConnell - Journal of the American Heart …, 2020 - Am Heart Assoc
Heart failure is a complex clinical syndrome, represented as an impairment in ventricular
filling and myocardial blood ejection. As such, heart failure is one of the leading causes of …

[HTML][HTML] Liraglutide improves lipid metabolism by enhancing cholesterol efflux associated with ABCA1 and ERK1/2 pathway

YR Wu, XY Shi, CY Ma, Y Zhang, RX Xu… - Cardiovascular diabetology, 2019 - Springer
Background Reverse cholesterol transport (RCT) is an important cardioprotective
mechanism and the decrease in cholesterol efflux can result in the dyslipidemia. Although …

[HTML][HTML] Proteomics analysis of adipose depots after intermittent fasting reveals visceral fat preservation mechanisms

DJ Harney, M Cielesh, R Chu, KC Cooke, DE James… - Cell reports, 2021 - cell.com
Intermittent fasting is a beneficial dietary treatment for obesity. But the response of each
distinct adipose depot is currently poorly defined. Here we explore the response of key …

Curcumin nanoemulsion counteracts hepatic and cardiac complications associated with high‐fat/high‐fructose diet in rats

MA Elbaset, M Nasr, BMM Ibrahim… - Journal of Food …, 2022 - Wiley Online Library
The relationship between the incidence of cardiovascular abnormalities and non‐alcoholic
fatty liver disease (NAFLD) has long been postulated. Curcumin (CUR) is a potential anti …

Physiologic and pathophysiologic roles of AKAP12

H Li - Science Progress, 2022 - journals.sagepub.com
A kinase anchoring protein (AKAP) 12 is a scaffolding protein that improves the specificity
and efficiency of spatiotemporal signal through assembling intracellular signal proteins into …

Development of stem cell therapy for atherosclerosis

Y Ma, T Gu, S He, S He, Z Jiang - Molecular and Cellular Biochemistry, 2024 - Springer
Cardiovascular disease (CVD) has a high incidence and low cure rate worldwide, and
atherosclerosis (AS) is the main factor inducing cardiovascular disease, of which lipid …

[HTML][HTML] Novel insight into the role of A-kinase anchoring proteins (AKAPs) in ischemic stroke and therapeutic potentials

Z He, L Xie, J Liu, X Wei, W Zhang, Z Mei - Biomedicine & Pharmacotherapy, 2024 - Elsevier
Ischemic stroke, a devastating disease associated with high mortality and disability
worldwide, has emerged as an urgent public health issue. A-kinase anchoring proteins …

AKAP12 Upregulation Associates With PDE8A to Accelerate Cardiac Dysfunction

H Qasim, M Rajaei, Y Xu, A Reyes-Alcaraz… - Circulation …, 2024 - Am Heart Assoc
BACKGROUND: In heart failure, signaling downstream the β2-adrenergic receptor is critical.
Sympathetic stimulation of β2-adrenergic receptor alters cAMP (cyclic adenosine 3′, 5 …

[HTML][HTML] Targeted disruption of PKC from AKAP signaling complexes

AJ Limaye, GN Bendzunas, EJ Kennedy - RSC Chemical Biology, 2021 - pubs.rsc.org
Protein Kinase C (PKC) is a member of the AGC subfamily of kinases and regulates a wide
array of signaling pathways and physiological processes. Protein–protein interactions …