The physiological stress response is responsible for the maintenance of homeostasis in the
presence of real or perceived challenges. In this function, the brain activates adaptive …

The CRH receptor (CRH-R) is a member of the secretin family of G protein-coupled
receptors. Wide expression of CRH-Rs in the central nervous system and periphery ensures …

Corticotropin-releasing factor (CRF) and the related urocortin peptides mediate behavioral,
cognitive, autonomic, neuroendocrine and immunologic responses to aversive stimuli by …

Background: Corticotropin-releasing factor (CRF) pathways coordinate behavioral,
endocrine, autonomic and visceral responses to stress. Convergent anatomical, molecular …

Markers of hyperactive central corticotropin releasing factor (CRF) systems and CRF‐related
single nucleotide polymorphisms (SNPs) have been identified in patients with anxiety and …

Over the course of the last 50 years many models of major depressive disorder have been
developed on the basis of theoretical aspects of this disorder. These models and procedures …

Urocortins, three paralogs of the stress-related peptide corticotropin-releasing factor (CRF)
found in bony fish, amphibians, birds, and mammals, have unique phylogenies …

The long-term impact of early stress on behavior and emotions is well documented in
humans, and can be modeled in experimental animals. In mice, maternal separation during …

Rationale Corticotropin-releasing factor (CRF) produces anxiety-like and aversive effects
when infused directly into the various regions of the brain, including the bed nucleus of the …

Environmental stress has been demonstrated to increase susceptibility for mood and anxiety
disorders, and hyperactivity of the hypothalamic–pituitary–adrenal (HPA) axis, the primary …