Approximately 10% of breast cancers are associated with the inheritance of a pathogenic
variant (PV) in one of the breast cancer susceptibility genes. Multiple breast cancer …

Hereditary breast and ovarian cancer syndrome (HBOC) is clinically defined by family
history criteria, and molecularly defined by identification of germline pathogenic variants …

Background Healthy individuals and patients with cancer who are carriers of germline
pathogenic variants in the BRCA1/2 genes face multiple reproductive challenges that …

Fertility preservation is a major concern in young patients diagnosed with breast cancer and
planning to receive multimodality treatment, including gonadotoxic chemotherapy with or …

Purpose Although the role of CHEK2 germline pathogenic variants in cancer predisposition
is well known, resources for managing CHEK2 heterozygotes in clinical practice are limited …

Background Although use of gonadotropin-releasing hormone agonist (GnRHa) during
chemotherapy is an established strategy to protect ovarian function in premenopausal …

STUDY QUESTION Is there an efficient and cost-effective detection platform for different
genetic conditions about embryos? SUMMARY ANSWER A multifunctional haplotyping …

Hereditary cancer syndromes are a heterogeneous group of genetic conditions that are
associated with an increased risk of developing cancer during lifespan. In affected women …

Simple Summary Preimplantation genetic testing (PGT) has been developed to avoid the
transmission of a critical hereditary disease, by selecting embryos for uterine transfer using a …

Background Knowledge is growing on the safety of assisted reproductive techniques (ART)
in cancer survivors. No data exist, however, for the specific population of breast cancer …