In vivo models in breast cancer research: progress, challenges and future directions
Research using animal model systems has been instrumental in delivering improved
therapies for breast cancer, as well as in generating new insights into the mechanisms that …
therapies for breast cancer, as well as in generating new insights into the mechanisms that …
Predictive, preventive, and personalized medicine in breast cancer: targeting the PI3K pathway
M Tufail, JJ Hu, J Liang, CY He, WD Wan… - Journal of Translational …, 2024 - Springer
Breast cancer (BC) is a multifaceted disease characterized by distinct molecular subtypes
and varying responses to treatment. In BC, the phosphatidylinositol 3-kinase (PI3K) pathway …
and varying responses to treatment. In BC, the phosphatidylinositol 3-kinase (PI3K) pathway …
[HTML][HTML] Label-free virtual HER2 immunohistochemical staining of breast tissue using deep learning
B DoanNgan, DM Angus, LH Sung - BME frontiers, 2022 - spj.science.org
The immunohistochemical (IHC) staining of the human epidermal growth factor receptor 2
(HER2) biomarker is widely practiced in breast tissue analysis, preclinical studies, and …
(HER2) biomarker is widely practiced in breast tissue analysis, preclinical studies, and …
Emergence of ERBB2 Mutation as a Biomarker and an Actionable Target in Solid Cancers
The oncogenic role ERBB2 amplification is well established in breast and gastric cancers.
This has led to the development of a well‐known portfolio of monoclonal antibodies and …
This has led to the development of a well‐known portfolio of monoclonal antibodies and …
From chaos to opportunity: decoding cancer heterogeneity for enhanced treatment strategies
A Ottaiano, M Ianniello, M Santorsola, R Ruggiero… - Biology, 2023 - mdpi.com
Simple Summary Cancer is a complex illness marked by aberrant cellular behaviors and
genetic variances, resulting in tumor heterogeneity that presents challenges in cancer …
genetic variances, resulting in tumor heterogeneity that presents challenges in cancer …
Combining losartan with radiotherapy increases tumor control and inhibits lung metastases from a HER2/neu-positive orthotopic breast cancer model
W Li, S Li, IX Chen, Y Liu, RR Ramjiawan, CH Leung… - Radiation …, 2021 - Springer
Background Patients with metastatic HER2/neu-positive (HER2/neu+) breast cancer (BC)
often experience treatment resistance, disease recurrences and metastases. Thus, new …
often experience treatment resistance, disease recurrences and metastases. Thus, new …
HO-1 drives autophagy as a mechanism of resistance against HER2-targeted therapies
N Tracey, H Creedon, AJ Kemp, J Culley… - Breast Cancer Research …, 2020 - Springer
Purpose Targeted therapies have resulted in major advances in the treatment of HER2-
positive breast cancers. Despite this, up to 70% of patients will develop resistance to …
positive breast cancers. Despite this, up to 70% of patients will develop resistance to …
Mouse models of overexpression reveal distinct oncogenic roles for different type I protein arginine methyltransferases
Protein arginine methyltransferases (PRMT) are generally not mutated in diseased states,
but they are overexpressed in a number of cancers, including breast cancer. To address the …
but they are overexpressed in a number of cancers, including breast cancer. To address the …
[HTML][HTML] Clinical applications of mouse models for breast cancer engaging HER2/neu
Abstract Human c-ErbB2 (HER2) has long been used as a marker of breast cancer (BC) for
sub-categorization for the prediction of prognosis, and determination of therapeutic …
sub-categorization for the prediction of prognosis, and determination of therapeutic …
Development of mouse models of angiosarcoma driven by p53
DM Salter, M Griffin, M Muir, K Teo… - Disease Models & …, 2019 - journals.biologists.com
Angiosarcomas are a rare group of tumours which have poor prognosis and limited
treatment options. The development of new therapies has been hampered by a lack of good …
treatment options. The development of new therapies has been hampered by a lack of good …