Toll-like receptor polymorphisms, inflammatory and infectious diseases, allergies, and cancer

AE Medvedev - Journal of Interferon & Cytokine Research, 2013 - liebertpub.com
Toll-like receptors (TLRs) are germ-line-encoded innate immune sensors that recognize
conserved microbial structures and host alarmins and signal expression of MHC proteins …

New findings of Toll-like receptors involved in Mycobacterium tuberculosis infection

M Faridgohar, H Nikoueinejad - Pathogens and global health, 2017 - Taylor & Francis
Tuberculosis (TB), an important issue in the present age, affects millions of people each
year. The infectious agent of TB, Mycobacterium tuberculosis (Mtb), interacts with the …

[HTML][HTML] Genetic polymorphisms of IL-17A, IL-17F, TLR4 and miR-146a in association with the risk of pulmonary tuberculosis

M Wang, G Xu, L Lü, K Xu, Y Chen, H Pan… - Scientific reports, 2016 - nature.com
Genetic factors affect host susceptibility to pathogens. In this population-based case control
study, we explored the genetic polymorphisms of IL-17, TLR4 and miR-146a in association …

Association of toll-like receptors 1, 2, 4, 6, 8, 9 and 10 genes polymorphisms and susceptibility to pulmonary tuberculosis in Sudanese patients

NA Mhmoud - ImmunoTargets and Therapy, 2023 - Taylor & Francis
Background Genetic factors are important contributors to the development of a wide range of
complex disease. Polymorphisms in genes encoding for toll-like receptors (TLRs) usually …

[HTML][HTML] Variants in toll-like receptor 9 gene influence susceptibility to tuberculosis in a Mexican population

D Torres-García, A Cruz-Lagunas… - Journal of translational …, 2013 - Springer
Abstract Background The control of Mycobacterium tuberculosis (Mtb) infection begins with
the recognition of mycobacterial structural components by toll like receptors (TLRs) and …

[HTML][HTML] Genomics of human pulmonary tuberculosis: from genes to pathways

CM Stein, L Sausville, C Wejse, RS Sobota… - … genetic medicine reports, 2017 - Springer
Abstract Purpose of Review Tuberculosis (TB), caused by Mycobacterium tuberculosis
(MTB), remains a major public health threat globally. Several lines of evidence support a …

Genetic variation in TLR pathway and the risk of pulmonary tuberculosis in a Moldavian population

A Varzari, IV Deyneko, I Vladei, H Grallert… - Infection, Genetics and …, 2019 - Elsevier
Toll-like receptors (TLRs) play a critical role in initiating an immune response to infections. In
this study, we examined whether single nucleotide polymorphisms (SNPs) in TLR pathway …

Toll-Like Receptor 4 as an Immune Receptor Against Mycobacterium tuberculosis: A Systematic Review

Z Sepehri, Z Kiani, F Kohan, S Ghavami - Laboratory Medicine, 2019 - academic.oup.com
Objective To review the main Mycobacterium tuberculosis (Mtb) pathogen-associated
molecular patterns (PAMPs) and the roles played by toll-like receptor (TLR) 4 in …

Toll-like receptors in mycobacterial infection

A Vu, A Calzadilla, S Gidfar… - European journal of …, 2017 - Elsevier
Toll-like receptors are transmembrane glycoproteins predominantly expressed in tissues
with immune function. They are considered one of the most important pattern recognition …

[HTML][HTML] Germline genetic variants of viral entry and innate immunity may influence susceptibility to SARS-CoV-2 infection: toward a polygenic risk score for risk …

VK Grolmusz, A Bozsik, J Papp, A Patócs - Frontiers in Immunology, 2021 - frontiersin.org
The ongoing COVID-19 pandemic caused by the novel coronavirus, SARS-CoV-2 has
affected all aspects of human society with a special focus on healthcare. Although older …