Conspectus Lipid nanoparticles (LNPs) are a type of lipid vesicles that possess a
homogeneous lipid core. These vesicles are widely used in small-molecule drug and …

Lipid nanoparticles (LNPs) have emerged across the pharmaceutical industry as promising
vehicles to deliver a variety of therapeutics. Currently in the spotlight as vital components of …

Delivery of genetic information to the interior of target cells in vivo has been a major
challenge facing gene therapies. This barrier is now being overcome, owing in part to …

Alzheimer's disease (AD) and treatment of the brain in aging require the development of
new biologic drugs, such as recombinant proteins or gene therapies. Biologics are large …

Lipid nanoparticle (LNP) packaged mRNA vaccines have been deployed against infectious
diseases such as COVID-19, yet their structural features remain unclear. Cholesterol, a …

We have structurally characterized the liquid crystal (LC) phase that can appear as an
intermediate state when a dielectric nematic, having polar disorder of its molecular dipoles …

Polysarcosine (pSar) is a polypeptoid based on the endogenous amino acid sarcosine (N-
methylated glycine), which has previously shown potent stealth properties. Here, lipid …

RNA therapeutics have the potential to resolve a myriad of genetic diseases. Lipid
nanoparticles (LNPs) are among the most successful RNA delivery systems. Expanding their …

With the rapid development of nanotechnology in the recent decade, novel DNA and RNA
delivery systems for gene therapy have become available that can be used instead of viral …

Ionisable amino‐lipid is a key component in lipid nanoparticles (LNPs), which plays a crucial
role in the encapsulation of RNA molecules, allowing efficient cellular uptake and then …