In performing its multiple cellular functions, the cytoplasmic dynein motor is subject to
complex regulation involving allosteric mechanisms within the dynein complex, as well as …

Light microscopy is a powerful tool for probing the conformations of molecular machines at
the single-molecule level. Single-molecule Förster resonance energy transfer can measure …

Cytoplasmic dynein moves processively along microtubules, but the mechanism of how its
heads use the energy from ATP hydrolysis, coupled to a linker swing, to achieve directed …

Dyneins are the largest of the cytoskeletal motor proteins, and their mechanochemical
behavior is complex. Recent high-resolution crystallographic structures have revealed new …

Dynein interacts with microtubules through a dedicated binding domain that is dynamically
controlled to achieve high or low affinity, depending on the state of nucleotide bound in a …

This book draws together recent data on both cytoplasmic and flagellar dyneins and the
proteins they interact with, to give readers a clear picture of what is currently known about …

Unlike our understanding of the other two classes of cytoskeletal motor proteins, the myosins
and kinesins, we have only recently begun to comprehend the molecular mechanism for …

Measuring dynamics and distance changes of macromolecules provides insight into how
molecular machines function. While single-molecule methods for measuring distances …

In Paramecium multimicronucleatum, the discoidal vesicles, the acidosomes and the 100-
nm carrier vesicles are involved in phagosome formation, phagosome acidification and …

This thesis comprises the study of two pharmaceutically interesting lyase enzymes which
catalyze breaking a bond between a saccharide moiety and another moiety, facilitated by …