Recently, numerous evidence has revealed that excessive reactive oxygen species (ROS)
production and mitochondrial disruption during acute lung injury (ALI) and its most severe …

Acute respiratory distress syndrome (ARDS) is a major cause of patient mortality in intensive
care units (ICUs) worldwide. Considering that no causative treatment but only symptomatic …

Complex in vitro models of the tissue microenvironment, termed microphysiological systems,
have enormous potential to transform the process of discovering drugs and disease …

Mechanical ventilation (MV) may negatively affect the lungs and cause the release of
inflammatory mediators, resulting in extra-pulmonary organ dysfunction. Studies have …

Background As one of the basic treatments performed in the intensive care unit, mechanical
ventilation can cause ventilator-induced acute lung injury (VILI). The typical features of VILI …

By employing a reductionistic (but not simplistic) approach using an established invertebrate
model system, the pond snail Lymnaea stagnalis, we investigated whether (1) …

Mechanical ventilation of lungs suffering from microatelectases may trigger the development
of acute lung injury (ALI). Direct lung injury by bleomycin results in surfactant dysfunction …

Ventilator-induced lung injury (VILI) is a serious acute injury to the lung tissue that can
develop during mechanical ventilation of patients. Due to the mechanical strain of …

Positive pressure ventilation gained widespread clinical acceptance during the Danish polio
epidemic of 1952, 1 when it dramatically reduced the mortality of respiratory failure, and it …

Mechanical ventilation triggers the manifestation of lung injury and pre-injured lungs are
more susceptible. Ventilation-induced abnormalities of alveolar surfactant are involved in …