DNA–protein crosslinks and their resolution
P Weickert, J Stingele - Annual Review of Biochemistry, 2022 - annualreviews.org
Covalent DNA–protein crosslinks (DPCs) are pervasive DNA lesions that interfere with
essential chromatin processes such as transcription or replication. This review strives to …
essential chromatin processes such as transcription or replication. This review strives to …
[HTML][HTML] Replication-coupled DNA repair
D Cortez - Molecular cell, 2019 - cell.com
The replisome quickly and accurately copies billions of DNA bases each cell division cycle.
However, it can make errors, especially when the template DNA is damaged. In these cases …
However, it can make errors, especially when the template DNA is damaged. In these cases …
[HTML][HTML] Transcription-coupled repair of DNA–protein cross-links depends on CSA and CSB
Covalent DNA–protein cross-links (DPCs) are toxic DNA lesions that block replication and
require repair by multiple pathways. Whether transcription blockage contributes to the …
require repair by multiple pathways. Whether transcription blockage contributes to the …
Mechanisms of DNA–protein crosslink repair
Covalent DNA–protein crosslinks (DPCs, also known as protein adducts) of topoisomerases
and other proteins with DNA are highly toxic DNA lesions. Of note, chemical agents that …
and other proteins with DNA are highly toxic DNA lesions. Of note, chemical agents that …
[HTML][HTML] Endogenous aldehyde-induced DNA–protein crosslinks are resolved by transcription-coupled repair
Y Oka, Y Nakazawa, M Shimada, T Ogi - Nature Cell Biology, 2024 - nature.com
DNA–protein crosslinks (DPCs) induced by aldehydes interfere with replication and
transcription. Hereditary deficiencies in DPC repair and aldehyde clearance processes …
transcription. Hereditary deficiencies in DPC repair and aldehyde clearance processes …
A conserved SUMO pathway repairs topoisomerase DNA-protein cross-links by engaging ubiquitin-mediated proteasomal degradation
Topoisomerases form transient covalent DNA cleavage complexes to perform their
reactions. Topoisomerase I cleavage complexes (TOP1ccs) are trapped by camptothecin …
reactions. Topoisomerase I cleavage complexes (TOP1ccs) are trapped by camptothecin …
[HTML][HTML] Transcription-coupled DNA–protein crosslink repair by CSB and CRL4CSA-mediated degradation
M van Sluis, Q Yu, M van der Woude… - Nature Cell …, 2024 - nature.com
DNA–protein crosslinks (DPCs) arise from enzymatic intermediates, metabolism or
chemicals like chemotherapeutics. DPCs are highly cytotoxic as they impede DNA-based …
chemicals like chemotherapeutics. DPCs are highly cytotoxic as they impede DNA-based …
[HTML][HTML] The FANCJ helicase unfolds DNA-protein crosslinks to promote their repair
D Yaneva, JL Sparks, M Donsbach, S Zhao, P Weickert… - Molecular cell, 2023 - cell.com
Endogenous and exogenous agents generate DNA-protein crosslinks (DPCs), whose
replication-dependent degradation by the SPRTN protease suppresses aging and liver …
replication-dependent degradation by the SPRTN protease suppresses aging and liver …
[HTML][HTML] Replication-coupled DNA-protein crosslink repair by SPRTN and the proteasome in Xenopus egg extracts
NB Larsen, AO Gao, JL Sparks, I Gallina, RA Wu… - Molecular cell, 2019 - cell.com
DNA-protein crosslinks (DPCs) are bulky lesions that interfere with DNA metabolism and
therefore threaten genomic integrity. Recent studies implicate the metalloprotease SPRTN in …
therefore threaten genomic integrity. Recent studies implicate the metalloprotease SPRTN in …
[HTML][HTML] The CMG helicase bypasses DNA-protein cross-links to facilitate their repair
Covalent DNA-protein cross-links (DPCs) impede replication fork progression and threaten
genome integrity. Using Xenopus egg extracts, we previously showed that replication fork …
genome integrity. Using Xenopus egg extracts, we previously showed that replication fork …