Ischemia and reperfusion (I/R) exerts multiple insults in microcirculation, frequently
accompanied by endothelial cell injury, enhanced adhesion of leukocytes, macromolecular …

Renal ischemia–reperfusion (I/R) is an important etiopathological mechanism of acute renal
failure (ARF). Despite improvements in the treatment of ARF, it is associated with significant …

Important sex differences in the onset and characteristics of cardiovascular disease are
evident, yet the mechanistic details remain unresolved. Men are more susceptible to …

Despite the fact that septic patients exhibit altered cardiac function, it is not considered a
major pathology during sepsis. Thus, the molecular mechanisms underlying sepsis-induced …

Background Acute myocardial infarction (AMI) is a common cardiovascular disease. This
study aimed to mine biomarkers associated with AMI to aid in clinical diagnosis and …

Although reperfusion of an ischemic organ is essential to prevent irreversible tissue
damage, it may amplify tissue injury. This study investigates the role of endogenous …

Studies in human as well as animal models demonstrate that females in the proestrus cycle
(ie, with high estrogen) tolerate trauma-hemorrhage and sepsis far better than males. The …

This study examined sex differences in the regulation of pro-and anti-apoptotic proteins in
cardiac hypertrophy and heart failure due to volume overload induced by arteriovenous (AV) …

Chronic endogenous testosterone exposure adversely affects proinflammatory and
proapoptotic signaling after ischemia/reperfusion; however, it remains unknown whether a …

Purpose: To investigate whether caffeic acid phenethyl ester (CAPE) has a protective effect
on retinal ischemia/reperfusion (I/R) injury in rats, and to determine the possible antioxidant …