Bafilomycins and concanamycins, two groups of the plecomacrolide-defined class of
macrolide antibiotics, have recently been recognized as important tools for studying the …

Natural products as immunosuppressive agents - Natural Product Reports (RSC Publishing)
DOI:10.1039/B001720P Royal Society of Chemistry View PDF VersionPrevious ArticleNext …

During the process of autophagy, autophagosomes undergo a maturation process
consisting of multiple fusions with endosomes and lysosomes, which provide an acidic …

Muscle atrophy occurs in many pathological states and results primarily from accelerated
protein degradation and activation of the ubiquitin-proteasome pathway. However, the …

Various ATPases have been tested for their sensitivity to naturally occurring unusual
macrolides and their chemically modified derivatives, which are structurally related to …

T cell activation by specific antigen results in a rapid and long-lasting downregulation of
triggered T cell receptors (TCRs). In this work, we investigated the fate of downregulated …

Dengue hemorrhagic fever, the severe form of dengue virus infection, is believed to be an
immunopathological response to a secondary infection with a heterologous serotype of …

In this study we have analyzed the interaction between in vitro cultured bone marrow stromal
cells (BMSC) and NK cells. Ex vivo-isolated NK cells neoexpressed the activation Ag CD69 …

How a drug distributes within highly compartmentalized mammalian cells can affect both the
activity and pharmacokinetic behavior. Many commercially available drugs are considered …

Background Chediak-Higashi syndrome (CHS) is a rare disorder caused by biallelic
mutations in the lysosomal trafficking regulator gene (LYST), resulting in formation of giant …