Background Widely used for acute pain management, the clinical benefit from perioperative
use of gabapentinoids is uncertain. The aim of this systematic review was to assess the …

Background Excessive opioid prescribing after surgery has contributed to the current opioid
crisis; however, the value of prescribing opioids at surgical discharge remains uncertain. We …

Importance Harms and benefits of opioids for chronic noncancer pain remain unclear.
Objective To systematically review randomized clinical trials (RCTs) of opioids for chronic …

Methods In developing this guideline, the steering committee followed standards for
trustworthy guidelines. 15 We included innovative approaches for key standards such as …

Background Interest in the use of cannabis and cannabinoids to treat chronic non-cancer
pain is increasing, because of their potential to reduce opioid dose requirements. We aimed …

Background Previous studies have reported an extremely unbalanced global access to
opioid analgesics. We aimed to determine contemporary trends and patterns of opioid …

Background Opioid analgesics play a key role in pain management but providing access
while mitigating risk of misuse and dependence remains a challenge. Tracking global …

In the pediatric population, pain is frequently under-recognized and inadequately treated.
Improved education and training of health care providers can positively impact the …

This study compared the effects of the pericapsular nerve group (PENG) block and supra-
inguinal fascia iliaca compartment block (FICB) on postoperative analgesia and quadriceps …

Opioid-free anesthesia (OFA) is used in surgery to avoid opioid-related side effects.
However, uncertainty exists in the balance between OFA benefits and risks. We searched for …