Neural tube defects are severe congenital malformations affecting around one in every 1000
pregnancies. An innovation in clinical management has come from the finding that closure of …

Neural tube defects (NTDs) are common complex congenital malformations resulting from
failure of the neural tube closure during embryogenesis. It is established that folic acid …

▪ Abstract Choline is an essential nutrient needed for the structural integrity and signaling
functions of cell membranes; for normal cholinergic neurotransmission; for normal muscle …

Spina bifida results from failure of fusion of the caudal neural tube, and is one of the most
common malformations of human structure. The causes of this disorder are heterogeneous …

Folate is a water-soluble B-vitamin and enzymatic cofactor that is necessary for the synthesis
of purine and thymidine nucleotides and for the synthesis of methionine from homocysteine …

The influence of folate nutritional status on various pregnancy outcomes has long been
recognized. Studies conducted in the 1950s and 1960s led to the recognition of prenatal …

The worldwide incidence of neural tube defects (NTDs) ranges from 1.0 to 10.0 per 1,000
births with almost equal frequencies between two major categories: anencephaly and spina …

Tetrahydrofolate (THF) polyglutamates are a family of cofactors that carry and chemically
activate one‐carbon units for biosynthesis. THF‐mediated one‐carbon metabolism is a …

Neural tube defects (NTDs) are common, severe congenital malformations whose causation
involves multiple genes and environmental factors. Although more than 200 genes are …

Spina bifida, anencephaly, and encephalocele are commonly grouped together and termed
neural tube defects (NTD). Failure of closure of the neural tube during development results …