Vascular endothelial growth factor (VEGF) receptor 3 (VEGFR-3)(also called VEGFR-3) is
activated by its specific ligand, VEGF-C, which promotes cancer progression. The VEGF …

Lymphatic vessels, comprising the secondary circulatory system in human body, play a
multifaceted role in maintaining homeostasis among various tissues and organs. They are …

Purpose: Vascular endothelial growth factor (VEGF) signaling is key to tumor angiogenesis
and is an important target in the development of anticancer drugs. However, VEGF receptor …

The metastatic spread of tumor cells is the most lethal aspect of cancer and often occurs via
the lymphatic vasculature. Both experimental tumor models and human clinicopathologic …

Molecular markers have the potential to serve not only as prognostic factors but may be
targets for new therapeutic strategies and predictors of response in a range of cancers …

Dissemination to draining lymph nodes is a frequent first step in prostate cancer metastasis.
Although tumors metastasize to lymph nodes via the lymphatics, the importance of …

Lymphatic metastasis of tumor cells represents a series of extremely complex and
sequential processes that include dissemination and invasion into surrounding stromal …

Lymph node involvement denotes a poor outcome for patients with prostate cancer. Our
group, along with others, has shown that initial tumor cell dissemination to regional lymph …

Angiogenesis is crucial for maintaining the supply of oxygen and nutrients required to
support solid tumour growth. Inhibitors of tumour blood vessel formation are therefore being …

Regional lymph node metastasis is a common event in solid tumors and is considered a
marker for dissemination, increased stage, and worse prognosis. Despite rapid advances in …