Parkinson's disease (PD) is an incurable, devastating disorder that is characterized by
pathological protein aggregation and neurodegeneration in the substantia nigra. In recent …

Maintenance of gastrointestinal health is challenging as it requires balancing multifaceted
processes within the highly complex and dynamic ecosystem of the gastrointestinal tract …

The intestinal epithelium has high intrinsic turnover rate, and the precise renewal of the
epithelium is dependent on the microenvironment. The intestine is innervated by a dense …

Highlights•Enteric glial cells (EGCs) are required for maintenance of gut tissue
homeostasis.•GFAP+ EGCs regulate the health of the intestinal epithelial barrier.•EGCs …

Functional somatic syndromes are increasingly diagnosed in chronically ill patients
presenting with an array of symptoms not attributed to physical ailments. Conditions such as …

Enteric glia are a fascinating population of cells. Initially identified in the gut wall as the
“support” cells of the enteric nervous system, studies over the past 20 years have unveiled a …

Under physiological or pathological conditions, transient receptor potential (TRP) channel
vanilloid type 1 (TRPV1) and TRP ankyrin 1 (TRPA1) possess the ability to detect a vast …

Nearly all patients with systemic sclerosis (SSc) are negatively affected by dysfunction in the
gastrointestinal tract, and the severity of gastrointestinal disease in SSc correlates with high …

Inflammatory bowel diseases (IBDs), including ulcerative colitis, and Crohn's disease, are
intestinal disorders characterized by chronic relapsing inflammation. A large proportion of …

The accumulating evidence linking bacteria in the gut and neurons in the brain (the
microbiota–gut–brain axis) has led to a paradigm shift in the neurosciences. Understanding …