Role of branched-chain amino acid metabolism in the pathogenesis of obesity and type 2 diabetes-related metabolic disturbances BCAA metabolism in type 2 …
F Vanweert, P Schrauwen, E Phielix - Nutrition & diabetes, 2022 - nature.com
Branched-chain amino acid (BCAA) catabolism has been considered to have an emerging
role in the pathogenesis of metabolic disturbances in obesity and type 2 diabetes (T2D) …
role in the pathogenesis of metabolic disturbances in obesity and type 2 diabetes (T2D) …
Metabolomics in diabetes and diabetic complications: insights from epidemiological studies
Q Jin, RCW Ma - Cells, 2021 - mdpi.com
The increasing prevalence of diabetes and its complications, such as cardiovascular and
kidney disease, remains a huge burden globally. Identification of biomarkers for the …
kidney disease, remains a huge burden globally. Identification of biomarkers for the …
Integrative approaches for large-scale transcriptome-wide association studies
Many genetic variants influence complex traits by modulating gene expression, thus altering
the abundance of one or multiple proteins. Here we introduce a powerful strategy that …
the abundance of one or multiple proteins. Here we introduce a powerful strategy that …
Metabolomics and metabolic diseases: where do we stand?
CB Newgard - Cell metabolism, 2017 - cell.com
Metabolomics, or the comprehensive profiling of small molecule metabolites in cells, tissues,
or whole organisms, has undergone a rapid technological evolution in the past two decades …
or whole organisms, has undergone a rapid technological evolution in the past two decades …
Metabolomics in prediabetes and diabetes: a systematic review and meta-analysis
M Guasch-Ferré, A Hruby, E Toledo, CB Clish… - Diabetes …, 2016 - Am Diabetes Assoc
OBJECTIVE To conduct a systematic review of cross-sectional and prospective human
studies evaluating metabolite markers identified using high-throughput metabolomics …
studies evaluating metabolite markers identified using high-throughput metabolomics …
Dietary supplementation with inulin-propionate ester or inulin improves insulin sensitivity in adults with overweight and obesity with distinct effects on the gut …
Objective To investigate the underlying mechanisms behind changes in glucose
homeostasis with delivery of propionate to the human colon by comprehensive and …
homeostasis with delivery of propionate to the human colon by comprehensive and …
Quantitative serum nuclear magnetic resonance metabolomics in large-scale epidemiology: a primer on-omic technologies
P Würtz, AJ Kangas, P Soininen… - American journal of …, 2017 - academic.oup.com
Detailed metabolic profiling in large-scale epidemiologic studies has uncovered novel
biomarkers for cardiometabolic diseases and clarified the molecular associations of …
biomarkers for cardiometabolic diseases and clarified the molecular associations of …
Branched-chain amino acids in metabolic signalling and insulin resistance
Branched-chain amino acids (BCAAs) are important nutrient signals that have direct and
indirect effects. Frequently, BCAAs have been reported to mediate antiobesity effects …
indirect effects. Frequently, BCAAs have been reported to mediate antiobesity effects …
A metabolic profile of all-cause mortality risk identified in an observational study of 44,168 individuals
Predicting longer-term mortality risk requires collection of clinical data, which is often
cumbersome. Therefore, we use a well-standardized metabolomics platform to identify …
cumbersome. Therefore, we use a well-standardized metabolomics platform to identify …
Quantitative serum nuclear magnetic resonance metabolomics in cardiovascular epidemiology and genetics
P Soininen, AJ Kangas, P Würtz, T Suna… - Circulation …, 2015 - Am Heart Assoc
Metabolomics is becoming common in epidemiology due to recent developments in
quantitative profiling technologies and appealing results from their applications for …
quantitative profiling technologies and appealing results from their applications for …