Lysosomal proteases play a crucial role in maintaining cell homeostasis. Human cathepsin
D manages protein turnover degrading misfolded and aggregated proteins and favors …

This review examines the role of impaired amyloid-β clearance in the accumulation of
amyloid-β in the brain and the periphery, which is closely associated with Alzheimer's …

Abstract 5q-associated spinal muscular atrophy (SMA) is a rare genetic disease caused by
mutations in the SMN1 gene, resulting in a loss of functional SMN protein and consecutive …

More than seven decades have passed since the discovery of a proteolytic activity within
crude tissue extracts that would become known as insulin-degrading enzyme (IDE) …

In Parkinson's disease, aggregates of α-synuclein within Lewy bodies and Lewy neurites
represent neuropathological hallmarks. However, the cellular and molecular mechanisms …

Background and purpose The therapeutic landscape of spinal muscular atrophy (SMA) has
changed dramatically during the past 4 years, but treatment responses differ remarkably …

Cerebral clearance of amyloid β‐protein (Aβ) is decreased in early‐onset and late‐onset
Alzheimer's disease (AD). Aβ is cleared from the brain by enzymatic degradation and by …

We aim to investigate the mechanisms underlying the beneficial effects of exercise
rehabilitation (ER) and/or astragaloside (AST) in counteracting amyloid-beta (Aβ) pathology …

Cathepsin B is a cysteine protease that is implicated in multiple aspects of Alzheimer's
disease pathogenesis. The endogenous inhibitor of this enzyme, cystatin B (CSTB) is …

The lysosome is responsible for protein and organelle degradation and homeostasis and
the cathepsins play a key role in maintaining protein quality control. Cathepsin D (CTSD), is …