Therapeutic implications and clinical manifestations of thymoquinone

M Alam, GM Hasan, MM Ansari, R Sharma, DK Yadav… - Phytochemistry, 2022 - Elsevier
Thymoquinone (TQ), a natural phytochemical predominantly found in Nigella sativa, has
been investigated for its numerous health benefits. TQ showed anti-cancer, anti-oxidant, and …

Microtubule-affinity regulating kinase 4: A potential drug target for cancer therapy

S Anwar, M Shahwan, GM Hasan, A Islam, MI Hassan - Cellular Signalling, 2022 - Elsevier
The human genome encodes more than 500 protein kinases that work by transferring the γ-
phosphate group from ATP to serine, threonine, or tyrosine (Ser/Thr/Tyr) residues. Various …

Structure‐based investigation of MARK4 inhibitory potential of Naringenin for therapeutic management of cancer and neurodegenerative diseases

S Anwar, S Khan, A Shamsi, F Anjum… - Journal of cellular …, 2021 - Wiley Online Library
MAP/microtubule affinity‐regulating kinase 4 (MARK4) is a member of serine/threonine
kinase family and considered an attractive drug target for many diseases. Screening of …

Myricetin inhibits breast and lung cancer cells proliferation via inhibiting MARK4

S Anwar, S Khan, F Anjum, A Shamsi… - Journal of Cellular …, 2022 - Wiley Online Library
Identifying novel molecules as potential kinase inhibitors are gaining significant attention
globally. The present study suggests Myricetin as a potential inhibitor of microtubule‐affinity …

MAP/Microtubule affinity regulating kinase 4 inhibitory potential of Irisin: A new therapeutic strategy to combat cancer and Alzheimer's Disease

R Waseem, S Anwar, S Khan, A Shamsi… - International journal of …, 2021 - mdpi.com
Irisin is a clinically significant protein playing a valuable role in regulating various diseases.
Irisin attenuates synaptic and memory dysfunction, highlighting its importance in Alzheimer's …

Investigating MARK4 inhibitory potential of Bacopaside II: targeting Alzheimer's disease

S Anwar, T Mohammad, MK Azhar, H Fatima… - International journal of …, 2023 - Elsevier
Microtubule affinity regulating kinase 4 (MARK4) is known to hyperphosphorylate tau
protein, which subsequently causes Alzheimer's disease (AD). MARK4 is a well-validated …

Targeting cyclin‐dependent kinase 6 by vanillin inhibits proliferation of breast and lung cancer cells: Combined computational and biochemical studies

M Yousuf, A Shamsi, A Queen… - Journal of Cellular …, 2021 - Wiley Online Library
Abstract Cyclin‐dependent kinase 6 (CDK6) is a member of serine/threonine kinase family,
and its overexpression is associated with cancer development. Thus, it is considered as a …

Cinnamomum zeylanicum Extract and its Bioactive Component Cinnamaldehyde Show Anti-Tumor Effects via Inhibition of Multiple Cellular Pathways

S Aggarwal, K Bhadana, B Singh, M Rawat… - Frontiers in …, 2022 - frontiersin.org
Cinnamomum zeylanicum is a tropical plant with traditional medicinal significance that
possesses antimicrobial, antifungal, anti-parasitic, and anti-tumor properties. Here, we have …

Investigating role of plumbagin in preventing neurodegenerative diseases via inhibiting microtubule affinity regulating kinase 4

M Adnan, D DasGupta, S Anwar, M Patel… - Journal of Molecular …, 2023 - Elsevier
Microtubule affinity regulating kinase 4 (MARK4) is associated with the progression of
neurodegeneration, cancer, cardiovascular diseases, obesity and other life-threatening …

Binding studies of caffeic and p-coumaric acid with α-amylase: Multispectroscopic and computational approaches deciphering the effect on advanced glycation end …

MS Khan, MS Alokail, AMH Alenad, N Altwaijry… - Molecules, 2022 - mdpi.com
Alpha-amylase (α-amylase) is a key player in the management of diabetes and its related
complications. This study was intended to have an insight into the binding of caffeic acid and …