Therapeutic implications and clinical manifestations of thymoquinone
Thymoquinone (TQ), a natural phytochemical predominantly found in Nigella sativa, has
been investigated for its numerous health benefits. TQ showed anti-cancer, anti-oxidant, and …
been investigated for its numerous health benefits. TQ showed anti-cancer, anti-oxidant, and …
Microtubule-affinity regulating kinase 4: A potential drug target for cancer therapy
The human genome encodes more than 500 protein kinases that work by transferring the γ-
phosphate group from ATP to serine, threonine, or tyrosine (Ser/Thr/Tyr) residues. Various …
phosphate group from ATP to serine, threonine, or tyrosine (Ser/Thr/Tyr) residues. Various …
Structure‐based investigation of MARK4 inhibitory potential of Naringenin for therapeutic management of cancer and neurodegenerative diseases
MAP/microtubule affinity‐regulating kinase 4 (MARK4) is a member of serine/threonine
kinase family and considered an attractive drug target for many diseases. Screening of …
kinase family and considered an attractive drug target for many diseases. Screening of …
Myricetin inhibits breast and lung cancer cells proliferation via inhibiting MARK4
Identifying novel molecules as potential kinase inhibitors are gaining significant attention
globally. The present study suggests Myricetin as a potential inhibitor of microtubule‐affinity …
globally. The present study suggests Myricetin as a potential inhibitor of microtubule‐affinity …
MAP/Microtubule affinity regulating kinase 4 inhibitory potential of Irisin: A new therapeutic strategy to combat cancer and Alzheimer's Disease
Irisin is a clinically significant protein playing a valuable role in regulating various diseases.
Irisin attenuates synaptic and memory dysfunction, highlighting its importance in Alzheimer's …
Irisin attenuates synaptic and memory dysfunction, highlighting its importance in Alzheimer's …
Investigating MARK4 inhibitory potential of Bacopaside II: targeting Alzheimer's disease
S Anwar, T Mohammad, MK Azhar, H Fatima… - International journal of …, 2023 - Elsevier
Microtubule affinity regulating kinase 4 (MARK4) is known to hyperphosphorylate tau
protein, which subsequently causes Alzheimer's disease (AD). MARK4 is a well-validated …
protein, which subsequently causes Alzheimer's disease (AD). MARK4 is a well-validated …
Targeting cyclin‐dependent kinase 6 by vanillin inhibits proliferation of breast and lung cancer cells: Combined computational and biochemical studies
Abstract Cyclin‐dependent kinase 6 (CDK6) is a member of serine/threonine kinase family,
and its overexpression is associated with cancer development. Thus, it is considered as a …
and its overexpression is associated with cancer development. Thus, it is considered as a …
Cinnamomum zeylanicum Extract and its Bioactive Component Cinnamaldehyde Show Anti-Tumor Effects via Inhibition of Multiple Cellular Pathways
S Aggarwal, K Bhadana, B Singh, M Rawat… - Frontiers in …, 2022 - frontiersin.org
Cinnamomum zeylanicum is a tropical plant with traditional medicinal significance that
possesses antimicrobial, antifungal, anti-parasitic, and anti-tumor properties. Here, we have …
possesses antimicrobial, antifungal, anti-parasitic, and anti-tumor properties. Here, we have …
Investigating role of plumbagin in preventing neurodegenerative diseases via inhibiting microtubule affinity regulating kinase 4
Microtubule affinity regulating kinase 4 (MARK4) is associated with the progression of
neurodegeneration, cancer, cardiovascular diseases, obesity and other life-threatening …
neurodegeneration, cancer, cardiovascular diseases, obesity and other life-threatening …
Binding studies of caffeic and p-coumaric acid with α-amylase: Multispectroscopic and computational approaches deciphering the effect on advanced glycation end …
Alpha-amylase (α-amylase) is a key player in the management of diabetes and its related
complications. This study was intended to have an insight into the binding of caffeic acid and …
complications. This study was intended to have an insight into the binding of caffeic acid and …