Giardia duodenalis: biology and pathogenesis

RD Adam - Clinical microbiology reviews, 2021 - Am Soc Microbiol
Giardia duodenalis captured the attention of Leeuwenhoek in 1681 while he was examining
his own diarrheal stool, but, ironically, it did not really gain attention as a human pathogen …

Ultrastructural Alterations of the Human Pathogen Giardia intestinalis after Drug Treatment

M Benchimol, AP Gadelha, W de Souza - Pathogens, 2023 - mdpi.com
This review presents the main cell characteristics altered after in vitro incubation of the
parasite with commercial drugs used to treat the disease caused by Giardia intestinalis. This …

Lipidome of extracellular vesicles from Giardia lamblia

CP Faria, B Ferreira, Á Lourenço, I Guerra, T Melo… - Plos one, 2023 - journals.plos.org
Extracellular vesicles (EVs)(exossomes, microvesicles and apoptotic bodies) have been
well acknowledged as mediators of intercellular communications in prokaryotes and …

Trophozoite fitness dictates the intestinal epithelial cell response to Giardia intestinalis infection

J Grüttner, JM van Rijn, P Geiser, A Florbrant… - PLoS …, 2023 - journals.plos.org
Giardia intestinalis is a non-invasive, protozoan parasite infecting the upper small intestine
of most mammals. Symptomatic infections cause the diarrhoeal disease giardiasis in …

[HTML][HTML] Multimodal regulation of encystation in Giardia duodenalis revealed by deep proteomics

B Balan, SJ Emery-Corbin, JJ Sandow… - International Journal for …, 2021 - Elsevier
Cyst formation in the parasitic protist Giardia duodenalis is critical to its transmission.
Existing proteomic data quantifies only 17% of coding genes transcribed during encystation …

Lipid metabolism in Giardia: a post-genomic perspective

M Yichoy, TT Duarte, A De Chatterjee, TL Mendez… - Parasitology, 2011 - cambridge.org
Giardia lamblia, a protozoan parasite, infects a wide variety of vertebrates, including
humans. Studies indicate that this anaerobic protist possesses a limited ability to synthesize …

The assembly of GM1 glycolipid-and cholesterol-enriched raft-like membrane microdomains is important for giardial encystation

A De Chatterjee, TL Mendez… - Infection and …, 2015 - Am Soc Microbiol
Although encystation (or cyst formation) is an important step of the life cycle of Giardia, the
cellular events that trigger encystation are poorly understood. Because membrane …

Giardia intestinalis and its endomembrane system*

M Benchimol, W de Souza - Journal of Eukaryotic Microbiology, 2022 - Wiley Online Library
Giardia intestinalis has unique characteristics, even in the absence of certain organelles. For
instance, Golgi and mitochondria are not found. On the other hand, there is a network of …

Giardiasis, drug resistance, and new target discovery

HF Tian, B Chen, JF Wen - Infectious Disorders-Drug Targets …, 2010 - ingentaconnect.com
Giardiasis is a worldwide parasitic disease caused by the protozoan Giardia lamblia in
humans and other animals, especially live stocks. Here, we briefly review the current state of …

Characterization of Cell Wall Lipids from the Pathogenic Phase of Paracoccidioides brasiliensis Cultivated in the Presence or Absence of Human Plasma

LVG Longo, ES Nakayasu, F Gazos-Lopes… - PLoS …, 2013 - journals.plos.org
Background The fungal cell wall is a complex and dynamic outer structure. In pathogenic
fungi its components interact with the host, determining the infection fate. The present work …