Ferroptosis: mechanisms and links with diseases
H Yan, T Zou, Q Tuo, S Xu, H Li, AA Belaidi… - Signal transduction and …, 2021 - nature.com
Ferroptosis is an iron-dependent cell death, which is different from apoptosis, necrosis,
autophagy, and other forms of cell death. The process of ferroptotic cell death is defined by …
autophagy, and other forms of cell death. The process of ferroptotic cell death is defined by …
The glomerular filtration barrier: a structural target for novel kidney therapies
IS Daehn, JS Duffield - Nature Reviews Drug Discovery, 2021 - nature.com
Loss of normal kidney function affects more than 10% of the population and contributes to
morbidity and mortality. Kidney diseases are currently treated with immunosuppressive …
morbidity and mortality. Kidney diseases are currently treated with immunosuppressive …
Mitochondrial disorders of the OXPHOS system
E Fernandez‐Vizarra, M Zeviani - FEBS letters, 2021 - Wiley Online Library
Mitochondrial disorders are among the most frequent inborn errors of metabolism, their
primary cause being the dysfunction of the oxidative phosphorylation system (OXPHOS) …
primary cause being the dysfunction of the oxidative phosphorylation system (OXPHOS) …
The role of mitochondria in neurodegenerative diseases: the lesson from Alzheimer's disease and Parkinson's disease
G Monzio Compagnoni, A Di Fonzo, S Corti… - Molecular …, 2020 - Springer
Although the pathogenesis of neurodegenerative diseases is still widely unclear, various
mechanisms have been proposed and several pieces of evidence are supportive for an …
mechanisms have been proposed and several pieces of evidence are supportive for an …
Biochemistry of mitochondrial coenzyme Q biosynthesis
JA Stefely, DJ Pagliarini - Trends in biochemical sciences, 2017 - cell.com
Coenzyme Q (CoQ, ubiquinone) is a redox-active lipid produced across all domains of life
that functions in electron transport and oxidative phosphorylation and whose deficiency …
that functions in electron transport and oxidative phosphorylation and whose deficiency …
Mitochondrial dysfunction in inherited renal disease and acute kidney injury
Mitochondria are increasingly recognized as key players in genetic and acquired renal
diseases. Most mitochondrial cytopathies that cause renal symptoms are characterized by …
diseases. Most mitochondrial cytopathies that cause renal symptoms are characterized by …
Mitochondrial dysfunction in the pathophysiology of renal diseases
R Che, Y Yuan, S Huang… - American Journal of …, 2014 - journals.physiology.org
Mitochondrial dysfunction has gained recognition as a contributing factor in many diseases.
The kidney is a kind of organ with high energy demand, rich in mitochondria. As such …
The kidney is a kind of organ with high energy demand, rich in mitochondria. As such …
Molecular mechanisms in early diabetic kidney disease: glomerular endothelial cell dysfunction
E Lassén, IS Daehn - International journal of molecular sciences, 2020 - mdpi.com
Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease (ESRD), with
prevalence increasing at an alarming rate worldwide and today, there are no known cures …
prevalence increasing at an alarming rate worldwide and today, there are no known cures …
Mitochondrial epilepsy, a challenge for neurologists
P Lopriore, F Gomes, V Montano, G Siciliano… - International journal of …, 2022 - mdpi.com
Primary mitochondrial diseases are relatively common inborn errors of energy metabolism,
with a combined prevalence of 1 in 4300. These disorders typically affect tissues with high …
with a combined prevalence of 1 in 4300. These disorders typically affect tissues with high …
The clinical maze of mitochondrial neurology
Mitochondrial diseases involve the respiratory chain, which is under the dual control of
nuclear and mitochondrial DNA (mtDNA). The complexity of mitochondrial genetics provides …
nuclear and mitochondrial DNA (mtDNA). The complexity of mitochondrial genetics provides …