Ferroptosis is an iron-dependent cell death, which is different from apoptosis, necrosis,
autophagy, and other forms of cell death. The process of ferroptotic cell death is defined by …

Loss of normal kidney function affects more than 10% of the population and contributes to
morbidity and mortality. Kidney diseases are currently treated with immunosuppressive …

Mitochondrial disorders are among the most frequent inborn errors of metabolism, their
primary cause being the dysfunction of the oxidative phosphorylation system (OXPHOS) …

Although the pathogenesis of neurodegenerative diseases is still widely unclear, various
mechanisms have been proposed and several pieces of evidence are supportive for an …

Coenzyme Q (CoQ, ubiquinone) is a redox-active lipid produced across all domains of life
that functions in electron transport and oxidative phosphorylation and whose deficiency …

Mitochondria are increasingly recognized as key players in genetic and acquired renal
diseases. Most mitochondrial cytopathies that cause renal symptoms are characterized by …

Mitochondrial dysfunction has gained recognition as a contributing factor in many diseases.
The kidney is a kind of organ with high energy demand, rich in mitochondria. As such …

Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease (ESRD), with
prevalence increasing at an alarming rate worldwide and today, there are no known cures …

Primary mitochondrial diseases are relatively common inborn errors of energy metabolism,
with a combined prevalence of 1 in 4300. These disorders typically affect tissues with high …

Mitochondrial diseases involve the respiratory chain, which is under the dual control of
nuclear and mitochondrial DNA (mtDNA). The complexity of mitochondrial genetics provides …