The impact of medium chain and polyunsaturated ω-3-fatty acids on amyloid-β deposition, oxidative stress and metabolic dysfunction associated with Alzheimer's …

J Mett - Antioxidants, 2021 - mdpi.com
Alzheimer's disease (AD), the most common cause of dementia in the elderly population, is
closely linked to a dysregulated cerebral lipid homeostasis and particular changes in brain …

Experimental approaches for altering the expression of Abeta‐degrading enzymes

DA Loeffler - Journal of neurochemistry, 2023 - Wiley Online Library
Cerebral clearance of amyloid β‐protein (Aβ) is decreased in early‐onset and late‐onset
Alzheimer's disease (AD). Aβ is cleared from the brain by enzymatic degradation and by …

Vitamin B12 attenuates changes in phospholipid levels related to oxidative stress in SH-SY5Y cells

EL Theiss, LV Griebsch, AA Lauer, D Janitschke… - Cells, 2022 - mdpi.com
Oxidative stress is closely linked to Alzheimer's disease (AD), and is detected peripherally
as well as in AD-vulnerable brain regions. Oxidative stress results from an imbalance …

Fecal 16S rRNA sequencing and multi-compartment metabolomics revealed gut microbiota and metabolites interactions in APP/PS1 mice

X Cheng, Y Tan, H Li, J Huang, D Zhao, Z Zhang… - Computers in Biology …, 2022 - Elsevier
Background Alzheimer's disease is a significant public health issue. Recent studies have
shown that the gut microbiota plays a vital role in the onset and development of Alzheimer's …

8-20 Fragment as an Anti-Fibrillogenic and Neuroprotective Agent: Advancing toward Efficient Alzheimer's Disease Treatment

S Zimbone, ML Giuffrida, G Sabatino… - ACS Chemical …, 2023 - ACS Publications
Alzheimer's disease (AD) is the most common cause of dementia, characterized by a
spectrum of symptoms associated with memory loss and cognitive decline with deleterious …

Supplementation of Medium-Chain Triglycerides Combined with Docosahexaenoic Acid Inhibits Amyloid Beta Protein Deposition by Improving Brain Glucose …

Z Wang, D Zhang, C Cheng, Z Lin, D Zhou, Y Sun, W Li… - Nutrients, 2023 - mdpi.com
The deterioration of brain glucose metabolism predates the clinical onset of Alzheimer's
disease (AD). Medium-chain triglycerides (MCTs) and docosahexaenoic acid (DHA) …

Is there evidence of a ketogenic effect of coconut oil? Commentary: Effect of the Mediterranean diet supplemented with nicotinamide riboside and pterostilbene and/or …

J Norgren, I Kåreholt, S Sindi - Frontiers in Nutrition, 2024 - frontiersin.org
We read with interest the article by Carrera-Juliá et al.(1) including analyses of the effects on
anthropometric outcomes of a Mediterranean diet (MeDi)—with a carbohydrate target at …

Methylxanthines induce a change in the ad/neurodegeneration-linked lipid profile in neuroblastoma cells

D Janitschke, AA Lauer, CM Bachmann… - International Journal of …, 2022 - mdpi.com
Alzheimer's disease (AD) is characterized by an increased plaque burden and tangle
accumulation in the brain accompanied by extensive lipid alterations. Methylxanthines …

Interdisciplinary Approaches to Deal with Alzheimer's Disease—From Bench to Bedside: What Feasible Options Do Already Exist Today?

I Ablinger, K Dressel, T Rott, AA Lauer, M Tiemann… - Biomedicines, 2022 - mdpi.com
Alzheimer's disease is one of the most common neurodegenerative diseases in the western
population. The incidence of this disease increases with age. Rising life expectancy and the …

Exchange broadening underlies the enhancement of IDE-dependent degradation of insulin by anionic membranes

Q Zheng, B Lee, MT Kebede, VA Ivancic… - ACS …, 2022 - ACS Publications
Insulin-degrading enzyme (IDE) is an evolutionarily conserved ubiquitous zinc
metalloprotease implicated in the efficient degradation of insulin monomer. However, IDE …