Advances in technology have allowed chemical sampling with high spatial resolution and
the manipulation and measurement of individual molecules. Adaptation of these approaches …

This Review addresses methods for obtaining sequence information directly from
unamplified genomic length DNA. Our generic starting point is a large piece of DNA that …

We demonstrate that single cells can be controllably compartmentalized within aqueous
microdroplets; using such an approach we perform high-throughput screening by detecting …

Expectations of a technological revolution are associated with nanotechnology, and indeed
the generation, modification and utilization of objects with tiniest dimensions already …

The online characterization and detection of individual droplets at high speeds, low analyte
concentrations, and perfect detection efficiencies is a significant challenge underpinning the …

Long admired for its informational role in the cell, DNA is now emerging as an ideal
molecule for molecular nanotechnology. Biologists and biochemists have discovered DNA …

Metallic subwavelength apertures can be used in epi-illumination fluorescence to achieve
focal volume confinement. Because of the near field components inherent to small metallic …

We describe a novel approach for optically detecting DNA translocation events through an
array of solid-state nanopores that potentially allows for ultra high-throughput, parallel …

Optofluidics is an emerging field that involves the use of fluids to modify optical properties
and the use of optical devices to detect flowing media. Ultimately, its value is highly …

Herein, we describe the development of a multilayer droplet microfluidic system for creating
concentration gradients and generating microdroplets of varying composition for high …