Measurement of the effects of drugs, mediators and infectious agents on various models of
lung disease, as well as assessment of lung function in the intact mouse has the potential for …

Measuring lung function in mice is essential for establishing the relevance of murine models
to human lung disease. However, making such measurements presents particular technical …

With mathematical and computational models furthering our understanding of lung
mechanics, function and disease, this book provides an all-inclusive introduction to the topic …

Lung injury and fibrosis represent the most significant outcomes of severe and acute lung
disorders, including COVID-19. However, there are still no effective drugs to treat lung injury …

Mechanisms underlying airway hyperresponsiveness are not yet fully elucidated. One of the
manifestations of airway inflammation is leakage of diverse plasma proteins into the airway …

Recruitment and derecruitment (R/D) of air spaces within the lung is greatly enhanced in
lung injury and is thought to be responsible for exacerbating injury during mechanical …

Th17 cells are a proinflammatory subset of effector T cells that have been implicated in the
pathogenesis of asthma. Their production of the cytokine IL-17 is known to induce local …

Rationale: Nuclear factor (NF)-κB is a prominent proinflammatory transcription factor that
plays a critical role in allergic airway disease. Previous studies demonstrated that inhibition …

Rationale: Asthma is characterized by increases in airway resistance, pulmonary
remodeling, and lung inflammation. The cytokine transforming growth factor (TGF)-β has …

Rationale: Allergically inflamed mice exhibit airway hyperresponsiveness to inhaled
methacholine, which computer simulations of lung impedance suggest is due to enhanced …