Asthma is a serious health and socioeconomic issue all over the world, affecting more than
300 million individuals. The disease is considered as an inflammatory disease in the airway …

Asthma and chronic obstructive pulmonary disease (COPD) are chronic inflammatory
diseases of the airway, although the drivers and site of the inflammation differ between …

Flexible bronchoscopy (FB) is a safe and frequently performed procedure for the
assessment, diagnosis, and treatment of patients with respiratory disease. The procedure …

BACKGROUND: Asthma is a complex disease involving gene and environment interactions.
Although atopy is a strong predisposing risk factor for asthma, local tissue susceptibilities …

This study was designed to examine the inflammatory process in the central and peripheral
airways of surgically resected lungs from asthmatic and nonasthmatic subjects. Lung …

According to international guidelines, the level and adjustment of antiinflammatory treatment
for asthma are based solely on symptoms and lung function. We investigated whether a …

Epithelial damage and airway remodeling are consistent features of bronchial asthma and
are correlated with disease chronicity, severity, and bronchial hyperreactivity. To examine …

Airway wall remodeling is an established pathological feature in asthma. Its causes are not
well understood, but one mediator of potential relevance is transforming growth factor-beta 1 …

Background: Tumour necrosis factor α (TNFα) is a major therapeutic target in a range of
chronic inflammatory disorders characterised by a Th1 type immune response in which …

Aspirin causes bronchoconstriction in aspirin-intolerant asthma (AIA) patients by triggering
cysteinyl-leukotriene (cys-LT) production, probably by removing PGE2-dependent inhibition …