The field of vascular biology has gained enormous insight from the use of Cre and inducible
Cre mouse models to temporally and spatially manipulate gene expression within the …

Intercellular junctions mediate adhesion and communication between adjoining endothelial
and epithelial cells. In the endothelium, junctional complexes comprise tight junctions …

Haematopoietic stem cells (HSCs) are the founder cells of the adult haematopoietic system,
and thus knowledge of the molecular program directing their generation during development …

Vascular endothelial (VE)-cadherin is a strictly endothelial specific adhesion molecule
located at junctions between endothelial cells. In analogy of the role of E-cadherin as major …

Epithelial-to-mesenchymal transition (EMT) is fundamental to both embryogenesis and
tumor metastasis. The Notch intercellular signaling pathway regulates cell fate determination …

The endothelium forms a selective semi-permeable barrier controlling bidirectional transfer
between blood vessel and irrigated tissues. This crucial function relies on the dynamic …

The ability to target gene deletion to a specific cellular compartment via the Cre/loxP system
has been a powerful tool in the analysis of broadly expressed genes. Here, we report the …

Vascular endothelium plays a crucial role in vascular homeostasis and tissue fluid balance.
To target endothelium for robust genome editing, we developed poly (ethylene glycol) …

Aims Hazardous environmental and genetic factors can damage endothelial cells to induce
atherosclerotic vascular disease. Recent studies suggest that class III deacetylase SIRT1 …

Members of the Foxo family, Foxo1 (Fkhr), Foxo3 (Fkhrl1), and Foxo4 (Afx), are mammalian
homologs of daf-16, which influences life span and energy metabolism in Caenorhabditis …