Recent development in acetyl-CoA carboxylase inhibitors and their potential as novel drugs
X Wu, T Huang - Future Medicinal Chemistry, 2020 - Taylor & Francis
Acetyl-CoA carboxylase (ACC), a critical enzyme in the regulation of fatty acid synthesis and
metabolism, has emerged as an attractive target for a plethora of emerging diseases, such …
metabolism, has emerged as an attractive target for a plethora of emerging diseases, such …
Filament structures unveil the dynamic organization of human acetyl-CoA carboxylase
Human acetyl–coenzyme A (CoA) carboxylases (ACCs) catalyze the carboxylation of acetyl-
CoA, which is the rate-limiting step in fatty acid synthesis. The molecular mechanism …
CoA, which is the rate-limiting step in fatty acid synthesis. The molecular mechanism …
Discovery, structure, and function of filamentous 3-methylcrotonyl-CoA carboxylase
methylcrotonyl-CoA carboxylase (MCC) is a biotin-dependent mitochondrial enzyme
necessary for leucine catabolism in most organisms. While the crystal structure of …
necessary for leucine catabolism in most organisms. While the crystal structure of …
Approaches to measuring the activity of major lipolytic and lipogenic enzymes in vitro and ex vivo
M Wilhelm, L Rossmeislová, M Šiklová - International Journal of …, 2022 - mdpi.com
Since the 1950s, one of the goals of adipose tissue research has been to determine lipolytic
and lipogenic activity as the primary metabolic pathways affecting adipocyte health and size …
and lipogenic activity as the primary metabolic pathways affecting adipocyte health and size …
Human acetyl-CoA carboxylase 1 is an isomerase: carboxyl transfer is activated by catalytic effect of isomerization
X Wang, Y Li, X Chen, Z Zhou… - The Journal of Physical …, 2019 - ACS Publications
Obesity and its related diseases such as cancer and diabetes are leading life-threatening
issues in the modern world. Thus, new drugs toward obesity and obesity-caused diseases …
issues in the modern world. Thus, new drugs toward obesity and obesity-caused diseases …
ACC Enziminin Metabolik Hastalıklarda Terapötik Hedef Olarak Değerlendirilmesi
M Şahin, Ö Yıldırım - Gazi Üniversitesi Fen Fakültesi Dergisi, 2022 - dergipark.org.tr
Lipotoxicity results from the excessive lipid accumulation in peripheral tissues, is main
contributing factor leading to metabolic diseases. Acetyl-CoA carboxylase (ACC) is a key …
contributing factor leading to metabolic diseases. Acetyl-CoA carboxylase (ACC) is a key …
[引用][C] ACC Enziminin Metabolik Hastalıklarda Terapötik Hedef Olarak 4 Değerlendirilmesi 5
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