Alzheimer's disease (AD) is characterized by progressive memory loss and cognitive
function deficits. There are two major pathological hallmarks that contribute to the …

The complexity of Alzheimer's disease (AD) complicates the search for effective treatments.
While the key roles of pathologically modified proteins has occupied a central role in …

Tau protein is implicated in the pathogenesis of Alzheimer's disease (AD) and other
tauopathies, but its physiological function is in debate. Mostly explored in the brain, tau is …

Cardiomyocytes are large (∼ 40,000 µm3), rod-shaped muscle cells that provide the
working force behind each heartbeat. These highly structured cells are packed with dense …

Tau microtubule-associated proteins, encoded by the MAPT gene, are mainly expressed in
neurons participating in axonal transport and synaptic plasticity. Six major isoforms …

Tau is a microtubule-associated protein widely distributed in the central nervous system
(CNS). The main function of tau is to promote the assembly of microtubules and stabilize …

Zinc, an abundant transition metal, serves as a signalling molecule in several biological
systems. Zinc transporters are genetically associated with cardiovascular diseases but the …

Heart disease remains the leading cause of morbidity and mortality worldwide. With the
advancement of modern technology, the role (s) of microtubules in the pathogenesis of heart …

Microtubules, a highly dynamic cytoskeleton, participate in many cellular activities including
mechanical support, organelles interactions, and intracellular trafficking. Microtubule …

The aggregation of amyloid-beta peptide and tau protein dysregulation are implicated to
play key roles in Alzheimer's disease pathogenesis and are considered the main …