The novel antidepressant mirtazapine has a dual mode of action. It is a noradrenergic and
specific serotonergic antidepressant (NaSSA) that acts by antagonizing the adrenergic α2 …

The class of serotonin and norepinephrine reuptake inhibitors (SNRIs) now comprises three
medications: venlafaxine, milnacipran, and duloxetine. These drugs block the reuptake of …

Mirtazapine is the first noradrenergic and specific serotonergic antidepressant ('NaSSA'). It is
rapidly and well absorbed from the gastrointestinal tract after single and multiple oral …

A number of therapeutic drugs with different structures and mechanisms of action have been
reported to undergo metabolic activation by Phase I or Phase II drug-metabolizing enzymes …

BACKGROUND: Based on an earlier pilot study, as well as a theoretical consideration of its
mechanism of action, we undertook a placebo-controlled, double-blind trial of mirtazapine in …

Background: Depressed individuals effectively treated with selective serotonin reuptake
inhibitors (SSRIs) often report persistent insomnia and require adjunctive sleep-promoting …

This study was a 10-week double-blind, placebo-controlled pilot trial of mirtazapine for
anxiety in youth with autism spectrum disorder (ASD). Participants were ages 5 to 17 years …

Third-generation antidepressants are a group of antidepressant agents of variable action,
not confined to serotonin reuptake inhibition. These agents include venlafaxine, reboxetine …

Introduction and Aims. As an antidepressant with sedative and anxiolytic properties,
mirtazapine may be an appropriate pharmacotherapy for methamphetamine withdrawal …

Dopaminergic mesolimbic and mesocortical systems are fundamental in hedonia and
motivation. Therefore their regulation should be central in understanding depression …